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Gene Information
Gene symbol: EGR1
Gene name: early growth response 1
HGNC ID: 3238
Synonyms: TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EGF | 1 hits |
| 2 | EGFR | 1 hits |
| 3 | EREG | 1 hits |
| 4 | HBEGF | 1 hits |
| 5 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20190820 | This study shows that in prostate cell lines in culture, Egr-1 overexpression correlated with an alteration of p53 activity because of the expression of SV40 large T-antigen or because of a mutation in the TP53 gene. |
| 2 | 20190820 | In cells containing altered p53 activity, Egr-1 expression was abolished by pharmacological inhibition or RNAi silencing of p53. |
| 3 | 20190820 | Egr-1 increased the transcription of HB-EGF (epidermal growth factor), amphiregulin and epiregulin, resulting in autocrine activation of the EGF receptor (EGFR) and downstream MEK/ERK cascade. |
| 4 | 20190820 | Thus, mutant p53 initiates a feedback loop that involves ERK1/2-mediated transactivation of Egr-1, which in turn increases the secretion of EGFR ligands and stimulates the EGFR signaling pathway. |