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Gene Information
Gene symbol: EIF2AK2
Gene name: eukaryotic translation initiation factor 2-alpha kinase 2
HGNC ID: 9437
Synonyms: PKR, EIF2AK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD80 | 1 hits |
| 2 | CD86 | 1 hits |
| 3 | CD8A | 1 hits |
| 4 | HLA-A | 1 hits |
| 5 | IFNB1 | 1 hits |
| 6 | IRF3 | 1 hits |
| 7 | ITGAL | 1 hits |
| 8 | KHDRBS1 | 1 hits |
| 9 | NFKB1 | 1 hits |
| 10 | NFKBIA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21994357 | Interestingly, we show that upon activation by anti-CD40 and gamma interferon (IFN-?), B cells from PKR(-/-) mice show diminished major histocompatibility complex class II (MHC II), CD80, and CD86 levels on the cell surface compared to wild-type (WT) mice. |
| 2 | 21994357 | Our data also show that PKR is necessary for optimal expression of adhesion molecules, such as CD11a and ICAM-1, that are necessary for homotypic aggregation of B cells. |
| 3 | 19596385 | In mouse embryonic fibroblasts (MEFs), MVA induction of IkappaBalpha depletion is dependent on the expression of mouse or human double-stranded RNA-activated protein kinase (PKR). |
| 4 | 19596385 | These results demonstrate that events during the early phase of MVA replication can induce PKR-mediated processes contributing both to the activation of NF-kappaB signaling, and to processes that may restrict viral replication. |
| 5 | 20585572 | The compromised LCMV control in the absence of PKR was multifactorial, and linked to less effective CD8+ T cell-mediated viral suppression, enhanced viral replication in cells, and lower steady state expression levels of IFN-responsive genes. |
| 6 | 19846517 | Our results reveal multiple consequences of C protein expression and document an important function for PKR as an enhancer of IFN-beta induction during measles virus infection. |
| 7 | 21543505 | Here, we report that in addition to PKR, NSs also promotes the degradation of the TFIIH subunit p62. |
| 8 | 22083261 | NSs induces a shut-off of host transcription including interferon (IFN)-beta mRNA(7,8) and promotes degradation of double-stranded RNA-dependent protein kinase (PKR) at the post-translational level.(9,10) IFN-beta is transcriptionally upregulated by interferon regulatory factor 3 (IRF-3), NF-kB and activator protein-1 (AP-1), and the binding of IFN-beta to IFN-alpha/beta receptor (IFNAR) stimulates the transcription of IFN-alpha genes or other interferon stimulated genes (ISGs)(11), which induces host antiviral activities, whereas host transcription suppression including IFN-beta gene by NSs prevents the gene upregulations of those ISGs in response to viral replication although IRF-3, NF-kB and activator protein-1 (AP-1) can be activated by RVFV7. . |