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Gene Information
Gene symbol: FASLG
Gene name: Fas ligand (TNF superfamily, member 6)
HGNC ID: 11936
Synonyms: FasL, CD178
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL2 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | CSF2 | 1 hits |
| 4 | CXCL2 | 1 hits |
| 5 | FAS | 1 hits |
| 6 | IFNG | 1 hits |
| 7 | IL1B | 1 hits |
| 8 | IL6 | 1 hits |
| 9 | SOCS1 | 1 hits |
| 10 | TNFSF10 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11276204 | Fas ligand (CD95L) is synthesized both on the cell surface membrane and in a soluble form. |
| 2 | 15800857 | Detailed analysis of HLA-A2-HCV(core_35-44) tetramer-positive T cells generated with LP20-44 revealed that in vitro immunization resulted in T cells that secreted IFN-gamma after antigen-specific restimulation and that upregulated expression of Fas ligand but not of perforin. |
| 3 | 16081851 | This regimen prolonged survival of the animals and induced tumor-specific CTLs that expressed TRAIL, which in concert with perforin and Fas ligand (FasL) was involved in the tumor-specific CTL activity of these cells. |
| 4 | 18386791 | Gene transfer of Fas ligand (FasL) to tumor cells has been demonstrated to inhibit tumor growth in vivo, and neutrophils are primarily responsible for this immunoprotection. |
| 5 | 18386791 | Our data show that FasL-induced pathway triggers expression of proinflammatory cytokines, including IL-1 beta, IL-6, MIP-2 and MCP-1, while GM-CSF-dependent pathway promotes functional maturation and activation of DCs. |
| 6 | 18627219 | We also characterized human papillomavirus type 16 (HPV-16) E7-specific CD8(+) T cell immune responses in mice immunized with E7 DNA and DNA encoding shRNA targeting Fas ligand (FasL), a key proapoptotic signaling protein. |
| 7 | 19234198 | Fas ligand (FasL) is a major immune effector molecule that can contribute to the clearance of respiratory viruses. |
| 8 | 20097864 | Multiple immune-effector molecules play a role in antimicrobial immunity mediated by memory CD8 T cells, including IFN-gamma, perforin, TRAIL, Fas ligand, and TNF-alpha. |
| 9 | 20637014 | The suppression was dependent on the presence of Fas ligand (FasL) in the cecum, whereas it was independent of FasL in the spleen and in the liver, as revealed by the use of gld/gld mice as the recipients of vaccination, and transplantation of tumor cells expressing MUC1. |
| 10 | 21479379 | SOCS1-silencing in DCs could prevent immune tolerance by inhibiting Fas and Fas-L expression, induced by an increase in IL-12p70 and IL-6 production. |