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Gene Information

Gene symbol: FOS

Gene name: FBJ murine osteosarcoma viral oncogene homolog

HGNC ID: 3796

Synonyms: c-fos, AP-1

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	CD40	1 hits
3	IL10	1 hits
4	IL18	1 hits
5	IL1B	1 hits
6	IL6	1 hits
7	MAP3K11	1 hits
8	MAPK1	1 hits
9	MAPK8	1 hits
10	NFKB1	1 hits
11	PHIP	1 hits
12	SPG7	1 hits
13	TLR7	1 hits

Related Sentences

#	PMID	Sentence
1	16168555	Furthermore, an electrophoretic mobility shift assay showed that PhIP inhibited DNA binding activity of nuclear factor for immunoglobulin kappa chain in B cells (NF-kappaB), activator protein-1 (AP-1) and nuclear factor of activated T cells (NF-AT), which are known to be responsible for IL-2 transcriptional activation.
2	16168555	These results suggest that PhIP has potential immunosuppressive effects by inhibiting T-cell proliferation and IL-2 expression through down regulation of ROS generation and thereby inhibiting NF-kappaB, AP-1 and NF-AT activation.
3	16399630	Furthermore, CHL attenuated the activation of NF-kappaB, NF-IL6 and AP-1, which are known to be responsible for IL-1beta gene expression, as determined by an electrophoretic mobility shift assay and an in vitro transfection assay using p(NF-kappaB)3-CAT, p(NF-IL6)3-CAT, and p(AP-1)3-CAT, respectively.
4	16893987	Activation of GA-12 (a repressor element of IL-12 p40), rather than suppression of promoter elements, such as binding sites for NF-kappaB, AP-1, and IRF-1, was detected in LPS-stimulated RAW264.7 cells, accompanying hyperactivation of extracellular signal-related kinase (ERK).
5	17257639	Consistent with its known role in the activation of the AP-1 pathway through JNK kinase, MLK3 was able to enhance Tat-dependent HIV transcription in vitro thus leading to an increase in infection signal.
6	19895210	For example, LT46 Nef is unable to bind AP-1 and AP-2 and therefore is inactive on CD4 endocytosis.
7	18228247	The stimulation of B cells through both CD40 and TLR7 therefore enhanced the production of cytokines through increased JNK signaling and AP-1 activity.
8	21031251	The innate immune response mainly represented by Toll-like receptors and Nod-like receptors that recognize their specific ligands, activate transcription factors as NF-kB, AP-1, CREB-1, inducing production of inflammatory cytokines such as IL -8, IL-12, IL-6, IL-1?, IL-18, TNF-? and IL-10.
9	21450974	An electrophoretic mobility shift assay showed that SP600125 inhibited PGN-induced NF-?B and AP-1 activation, whereas inhibition of the ERK pathway enhanced NF-?B activation, but with no effect on AP-1.
10	21450974	These results indicate that the JNK MAPK positively regulate PGN-induced iNOS and NO expression by activating NF-?B and AP-1 transcription factors, whereas the ERK pathway plays a negative regulatory role via affecting NF-?B activity.
11	21600652	Collectively, we suggest that S. aureus-induced IL-1? production requires lipid raft formation, activation of MAP kinases, and activation of transcription factors AP-1, CRE, and NF-?B.