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Gene Information
Gene symbol: FOXO3
Gene name: forkhead box O3
HGNC ID: 3821
Synonyms: AF6q21, FOXO2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | ERBB2 | 1 hits |
| 3 | IL2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21107437 | We found that mice treated with hN'-neu-Foxo3 shRNA showed greater reductions in tumor growth and longer survival times than mice treated with hN'-neu-scramble shRNA, indicating that the silencing of Foxo3 enhanced the antitumor efficacy of the HER-2/neu cancer vaccine. |
| 2 | 21107437 | Cytotoxicity analyses further revealed that the Foxo3 shRNA-enhanced antitumor effect was associated with significant increases in the number of functional CD8(+) T cells and in the levels of cytotoxic T lymphocytes activity. |
| 3 | 21107437 | Finally, Foxo3 suppression was shown to markedly improve the effect of the HER-2/neu DNA vaccine in limiting the growth and lung metastases of MBT-2 cells. |
| 4 | 21926463 | The lower survival levels observed in memory B cells from ST subjects were the result of disrupted IL-2 signaling that led to increased transcriptional activity of Foxo3a and increased expression of its proapoptotic target TRAIL. |