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Gene Information
Gene symbol: GAD2
Gene name: glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
HGNC ID: 4093
Synonyms: GAD65
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD79A | 1 hits |
| 2 | IDDM2 | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | IL4 | 1 hits |
| 5 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11160264 | This protection was GAD65-specific since NOD mice immunized with pDNA encoding hen egg lysozyme-IgGFc and IL-4 continued to develop diabetes. |
| 2 | 11418698 | We previously demonstrated that administration of plasmid DNAs (pDNAs) encoding IL-4 and a fragment of glutamic acid decarboxylase 65 (GAD65) fused to IgGFc induces GAD65-specific Th2 cells and prevents insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. |
| 3 | 11418698 | These results demonstrate that insulin- and GAD65-specific T cell reactivity induced by pDNA vaccination has distinct effects on the progression of IDDM. |
| 4 | 19752238 | Furthermore, suppression of T1D was dependent on beta cell-specific IL-10-secreting CD4+ T cells, although the frequency of GAD65-specific FoxP3-expressing CD4+ T cells was also increased in sIA(g7)-pGAD65 dimer vaccinated NOD mice. |
| 5 | 20406664 | Increased anti-GAD65 IgG1, serum IgA and unchanged IgG2a antibodies titers; together with an increase of IL-4, IL-10 production and a decrease of IFN-gamma production suggested possible activation of GAD65-specific Th2 immune responses. |