Ignet

Gene Information

Gene symbol: GZMB

Gene name: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

HGNC ID: 4709

Synonyms: CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT

Related Genes

#	Gene Symbol	Number of hits
1	CCL3	1 hits
2	CCND3	1 hits
3	CD4	1 hits
4	CD8A	1 hits
5	CD9	1 hits
6	CSF2	1 hits
7	CTLA4	1 hits
8	FCGR3A	1 hits
9	IFNG	1 hits
10	IL10	1 hits
11	IL12A	1 hits
12	IL2	1 hits
13	IL21	1 hits
14	LAMP1	1 hits
15	MS4A1	1 hits
16	PDCD1	1 hits
17	SPN	1 hits
18	TBX21	1 hits
19	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	21996099	We have previously shown that interleukin-21, a pleiotropic C ?-chain signaling cytokine, induces the expression of the cytotoxic molecules granzyme B (GrB) and perforin in vitro in CD8 T cells and NK cells of chronically HIV infected individuals.
2	15837235	In the SD group only, IFN-gamma:IL-10 ratios significantly correlated with serum antibody titers (R = .37 - .50, P < or = .01) and ex vivo granzyme B (Grz B) levels (R = .50-.65, P < or = .001).
3	16424164	Key features of NK cell activity were inhibited, including release of perforin but not granzyme B, as well as the expression of cyclin D3 and activation of the Jak3-mediated pathways.
4	17082611	IL-12/GM-CSF treatment promoted a rapid up-regulation of CD43 and CD69 on CD8+ effector/memory T cells, augmented their ability to produce IFN-gamma, and restored granzyme B expression.
5	17505023	These IL-17-producing CD8(+) cells exhibit a unique granzyme B(-)IFN-gamma(-)IL-10(-) phenotype.
6	17823271	HIV-1-specific helper-T-cell activity was studied by measuring the levels of interleukin 2 (IL-2) produced by peripheral blood mononuclear cells (PBMCs) and the granule-dependent CTL activity by measuring the intracellular levels of perforin and granzyme B expression in CD8+ T cells after stimulation with gag p24 antigen.
7	17823271	The levels of perforin and granzyme B expression in CD8+ T cells were also higher among EU individuals than among healthy controls.
8	17878354	Release kinetics of the cytolytic effector molecules granzyme B and perforin, as well as the expression of the degranulation marker CD107a and IFN-gamma were simultaneously studied in SIV Gag(164-172) KP9-specific CD8+ T cells from Mane-A*10+ pigtail macaques.
9	18322193	Moreover, memory CD8(+) T cells that release the DC-activating factor TNF-alpha before the release of cytotoxic granules induce DC expression of an endogenous granzyme B inhibitor PI-9 and protect DCs from CTL killing with similar efficacy as CD4(+) Th cells.
10	19358269	Gene-encoded MIP-1alpha applied 5 days prior to E7SH-immunization combined with IFN-gamma or IL-12 (3 days) or IL-2 (5 days) postimmunization lead to a significantly enhanced tumor response that was clearly associated with granzyme B secretion and target cells lysis.
11	19803378	The DCs that were pre-cultured with Peptide-25 specific CD4+ T cells together with OVA and Peptide-25 induced the proliferation and granzyme B production of OVA specific CD8+ T cells.
12	21041491	These antigens also induced granzyme B (cytotoxic) responses from CD8(+) T cells.
13	21148794	Notably, ?50% of Tc17 cells also expressed the co-inhibitory molecule CTLA-4, and only a minority (<20%) expressed granzyme B suggesting that these cells possess more of a regulatory than cytotoxic phenotype.
14	21039472	Additionally, activated CD8 T cells showed differences in the expression of Killer cell lectin-like receptor G1, L-selectin and B cell lymphoma-2 and produced granzyme B, indicating cytotoxic activity, and the initially high expression of T-box transcription factor TBX21 in malaria-activated CD4 T cells indicated an early T helper type 1 (Th1)-skewed immune response.
15	21383976	Here, measurements of granzyme B target cell activity and HIV-1-infected CD4+ T-cell elimination were applied for the first time to identify antiviral activities in recipients of a replication incompetent adenovirus serotype 5 (Ad5) HIV-1 recombinant vaccine and were compared with HIV-negative individuals and chronically infected patients, including a group of LTNP.
16	21518876	The IL-6 acted by inducing granzyme B production and reducing expression of inhibitory molecule PD1 on the surface of the primed CD8 T cells.
17	21491085	AFP-specific T cells could efficiently kill HepG2 HCC cells, and produced IL-2, IFN-?, TNF-?, perforin and granzyme B, with minimal production of IL-10 (a negative regulator of T cell activation).
18	21816072	LAIV inoculation enhanced expression of activating receptor NKG2D and chemokine receptor CXCR3 on peripheral blood NK cells from both nonsmokers and smokers in vitro but did not induce changes in CD16(+) NK cells or granzyme B activity in either group.
19	20018619	However, granzyme B expression, acquisition of CTL activity, and peripheral tissue-type chemokine responsiveness are features exclusively exhibited by CD8+ T cells activated by DC1s.
20	21978002	CD8?(-) NK cells were phenotypically characterized as CD3(-) CD14(-) CD20(-) CD8?(-) cells that express NK cell markers including CD16, CD56, granzyme B, perforin, NKG2D and KIR2D.