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Gene Information
Gene symbol: ICOS
Gene name: inducible T-cell co-stimulator
HGNC ID: 5351
Synonyms: AILIM, CD278
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL6 | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | IL12A | 1 hits |
| 4 | SFTPA1B | 1 hits |
| 5 | SFTPC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21636296 | We demonstrate that inducible costimulator (ICOS) provides a critical early signal to induce the transcription factor Bcl6, and Bcl6 then induces CXCR5, the canonical feature of Tfh cells. |
| 2 | 19050242 | We now demonstrate that ICOS(-/-), relative to wild-type, mice elicit a normal PS-specific IgG isotype response to Pn, despite marked inhibition of both the primary and secondary IgG anti-protein (i.e., PspA, PspC, and PsaA) response. |
| 3 | 19592276 | CD4(+) T cells primed with IL-12 induced B cells to produce immunoglobulins in a fashion dependent on IL-21 and inducible costimulator (ICOS), thus sharing fundamental characteristics with Tfh cells. |