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Gene Information
Gene symbol: IFNAR1
Gene name: interferon (alpha, beta and omega) receptor 1
HGNC ID: 5432
Synonyms: IFRC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | CXCL10 | 1 hits |
| 3 | IFNB1 | 1 hits |
| 4 | IRF3 | 1 hits |
| 5 | IRF5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20549206 | Both IFN-alphaR(-/-) and IFN-gamma(-/-) hosts failed to up-regulate the CXCL10 mRNA and recruit Tc1 cells to the tumor site, indicating non-redundant roles of type-1 and type-2 IFNs in the effects of poly-ICLC-assisted vaccines. |
| 2 | 18945463 | The increased activation of CD8+ T cells was dependent on IFN-beta signaling, as we saw no difference following infection of IFNAR-/- mice. |
| 3 | 21835795 | Using pDCs derived from genetic knockout mice, we show that the myxoma virus-induced innate immune response requires the endosomal DNA sensor TLR9 and its adaptor MyD88, transcription factors IRF5 and IRF7, and the type I IFN positive-feedback loop mediated by IFNAR1. |
| 4 | 22083261 | NSs induces a shut-off of host transcription including interferon (IFN)-beta mRNA(7,8) and promotes degradation of double-stranded RNA-dependent protein kinase (PKR) at the post-translational level.(9,10) IFN-beta is transcriptionally upregulated by interferon regulatory factor 3 (IRF-3), NF-kB and activator protein-1 (AP-1), and the binding of IFN-beta to IFN-alpha/beta receptor (IFNAR) stimulates the transcription of IFN-alpha genes or other interferon stimulated genes (ISGs)(11), which induces host antiviral activities, whereas host transcription suppression including IFN-beta gene by NSs prevents the gene upregulations of those ISGs in response to viral replication although IRF-3, NF-kB and activator protein-1 (AP-1) can be activated by RVFV7. . |