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Gene Information
Gene symbol: IL17C
Gene name: interleukin 17C
HGNC ID: 5983
Synonyms: IL-17C, CX2, IL-21, MGC126884, MGC138401
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2 | 1 hits |
| 2 | CD27 | 1 hits |
| 3 | CD28 | 1 hits |
| 4 | CD4 | 1 hits |
| 5 | CD40 | 1 hits |
| 6 | CD8A | 1 hits |
| 7 | IFNG | 1 hits |
| 8 | IL13 | 1 hits |
| 9 | IL15 | 1 hits |
| 10 | IL21 | 1 hits |
| 11 | IL2RA | 1 hits |
| 12 | LAMP1 | 1 hits |
| 13 | SILV | 1 hits |
| 14 | STAT1 | 1 hits |
| 15 | STAT3 | 1 hits |
| 16 | STAT5A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16424205 | Low concentrations of IL-21 (10 ng/ml) failed to reverse the inhibitory activity of CD4+CD25+ cells in an allogeneic MLR, whereas 60 ng/ml rIL-21 partially restored responder T cell proliferation. |
| 2 | 17000687 | We found that (a) cytokine DNAs generally increased CD8+ T-cell responses against gp100; (b) ligation to Fc domains further enhanced T-cell responses; (c) adjuvant effects were sensitive to timing of DNA injection; (d) the most efficacious individual adjuvants for improving tumor-free survival were IL-12/Ig, IL-15/Ig, IL-21/Ig, GM-CSF/Ig, and CCL21; and (e) combinations of IL-2/Ig+IL-12/Ig, IL-2/Ig+IL-15/Ig, IL-12/Ig+IL-15/Ig, and IL-12/Ig+IL-21/Ig were most active; and (f) increased adjuvanticity of cytokine/Ig fusion DNAs was not related to higher tissue levels or greater stability. |
| 3 | 17707061 | IL-21 secreting RenCa could be rejected in syngeneic mice by the activation of CD8 T cells and natural killer cells. |
| 4 | 20039320 | IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. |
| 5 | 20957227 | Sorted human CD19+CD27+ B cells were retrovirally transduced with the human B cell lymphoma (BCL)-6 and BCL-XL genes, and subsequently cultured in the presence of CD40-ligand and IL-21. |
| 6 | 20977918 | The administration of IL-21 upregulated cytotoxic effector function and the expression of the costimulatory molecule CD28. |
| 7 | 21257966 | We next demonstrated that this intrinsic IL-21 signaling was essential for the survival of activated CD8 T cells and the generation of long-lived memory cells. |
| 8 | 21257966 | We further revealed that IL-21 promoted CD8 T cell survival in a mechanism dependent on activation of the STAT1 and STAT3 pathways and subsequent upregulation of the prosurvival molecules Bcl-2 and Bcl-x(L). |
| 9 | 21257966 | These results identify a critical role for intrinsic IL-21 signaling in CD8 T cell responses to an acute viral infection in vivo and may help design effective vaccine strategies. |
| 10 | 21382487 | PBMC were stimulated polyclonally using CD40 Ligand, IL-21 and CpG to induce B cell proliferation and differentiation into antibody secreting cells (ASCs). |
| 11 | 21502921 | Secretion of the cytokine IL-21, by HIV-specific CD4 T cells, is associated with disease control and enhances the capacity of HIV-specific CD8 T cells to suppress viral replication. |
| 12 | 18670213 | IL-15 upregulated perforin expression primarily in CD56 NK cells, whereas IL-21 upregulated perforin in both NK subsets. |
| 13 | 18670213 | IL-21 and IL-15 upregulated CD107a and IFN-gamma, as well as NK cytotoxicity. |
| 14 | 18670213 | IL-15 predominantly activated STAT5, whereas IL-21 activated STAT5 and STAT3. |
| 15 | 18606647 | Treatment with Salmonella-CFA/I(IC) greatly reduced clinical disease, similarly as Salmonella-CFA/I, by subduing IL-17 and IL-21; however, mechanisms of protection differed as evident by increased IL-13 and IFN-gamma but diminished TGF-beta production by T(reg) cells from Salmonella-CFA/I(IC)-treated mice. |
| 16 | 19144318 | In the presence of IL-21, TGFbeta1 promoted naive B cell proliferation and differentiation and overrode IL-21-induced IgG class switching in favor of IgA. |