Ignet

Gene Information

Gene symbol: IL23A

Gene name: interleukin 23, alpha subunit p19

HGNC ID: 15488

Synonyms: SGRF, IL23P19, IL-23, IL-23A, P19

Related Genes

#	Gene Symbol	Number of hits
1	CASP1	1 hits
2	CD4	1 hits
3	CD40LG	1 hits
4	CD8A	1 hits
5	CLEC7A	1 hits
6	COL1A1	1 hits
7	IFNG	1 hits
8	IL12A	1 hits
9	IL13	1 hits
10	IL17A	1 hits
11	IL2	1 hits
12	IL23R	1 hits
13	MAPK1	1 hits
14	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	16369012	Three heterodimeric cytokines, interleukin-12 (IL-12), IL-23, and IL-27, as well as IL-18, contribute to the differentiation and expansion of naive CD4(+) T cells.
2	16369012	Supernatant from p2AIL-23-transfected cells induced the release of IL-17 from activated lymphocytes, confirming the presence of bioactive IL-23.
3	16621986	Although IL-23 specifically increased IFN-gamma production by tumor-specific T cells, IFN-gamma itself was not a primary mediator of the vaccine adjuvant effect.
4	16621986	The IL-23-induced antitumor effect and accompanying reversible weight loss were both partially mediated by TNF-alpha.
5	16621986	Under these conditions, it was also clear that enhanced effector function of vaccine-induced CD8(+) T cells, rather than increased T cell number, is a primary mechanism underlying the antitumor effect of IL-23.
6	18453582	However, upon restimulation with rhesus macaque CD154, GA/d-cAMP-activated DCs produced IL-12p40/IL-23.
7	19161425	IL-23 can induce IFN-gamma responses in the lung if IL-12 is not present, but its major role is in supporting the IL-17 response within the lung.
8	20434781	CS-A also up-regulated STAT3 and IL-23 expression and thus increased IL-17 producing T cells.
9	20504940	However, only the IL-22(+) IFN-gamma(-) lung NK subset was observed after stimulation with IL-23.
10	20504940	IL-23 receptor (IL-23R) blocking dramatically inhibited IL-22 production, but not IFN-gamma production.
11	21084465	By using an autovaccine approach, i.e., IL-12p70 cross-linked with ovalbumin and PADRE peptide formulated with the GSK proprietary adjuvant system AS02(V), we could specifically neutralize IL-12 while leaving the IL-23 axis intact.
12	21039466	Both immature and mature MoLCs secreted higher quantities of IL-23 compared with MoDCs and this finding correlated with a higher secretion of IL-17 in co-culture of MoLCs with allogeneic CD4(+) T cells.
13	21282337	Overall, our results suggest the potential of anti-human IL-23 mAbs to improve the immunostimulatory effects of IL-2 and trastuzumab in the current management of some advanced human cancers.
14	21490151	LT enhanced IL-23 and IL-1? production from DCs via activation of ERK MAPK and IL-1? secretion through activation of caspase-1 and the NLRP3 inflammasome.
15	19252500	In contrast, dectin-1 signaling mostly induced IL-23 and proinflammatory cytokines and augmented T(H)17 and T(H)1-mediated autoimmune responses in vivo.
16	21424108	After administrations of TNBS, vaccinated mice had significantly less body weight loss and a significant decrease of inflammatory scores, collagen deposition and expression of p40, IL-12, IL-23, IL-17, TNF, iNOS and Bcl-2 in colon tissues, compared with carrier and saline groups.
17	21746859	Here, we show that CD40L transduction of DCs results in the induction of interleukin-12p40 (IL-12p40), IL-12p70, and IL-23.
18	21746859	Antigen-specific recall responses in CD4-deficient mice were critically dependent on IL-12p40 and IL-23p19 expression in DCs and were not affected by the lack of IL-12p35.
19	19386801	Functional evaluation of the expanded number of CD4+ IL-23R+ cells in the presence of different cytokines with anti-CD3/CD28 revealed that all cytokines used (IL-2, IL-7, IL-12, IL-15, and IL-23) increased the amount of IFN-gamma secreted by IL-23R+ CD4+ cells at different levels.
20	22059995	Modified peptides induced higher IL-13 production than the wild-type, while the conserved peptides P16 and P19 induced the highest IFN-? and IL-13 and/or sCD30 release, respectively.