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Gene Information
Gene symbol: IL3
Gene name: interleukin 3 (colony-stimulating factor, multiple)
HGNC ID: 6011
Synonyms: IL-3, MULTI-CSF, MCGF, MGC79398, MGC79399
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGTR2 | 1 hits |
| 2 | AREG | 1 hits |
| 3 | CD34 | 1 hits |
| 4 | CD4 | 1 hits |
| 5 | CSF2 | 1 hits |
| 6 | FLT3 | 1 hits |
| 7 | IFNA1 | 1 hits |
| 8 | IFNG | 1 hits |
| 9 | IL1B | 1 hits |
| 10 | IL4 | 1 hits |
| 11 | IL5 | 1 hits |
| 12 | IL6 | 1 hits |
| 13 | ITGAM | 1 hits |
| 14 | KIT | 1 hits |
| 15 | KITLG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2017199 | IL-3 induces a mastocytosis and IL-5 an eosinophilia. |
| 2 | 2049044 | It is now believed that, at least in cutaneous leishmaniasis, Th2 subsets of CD4+ T cells are disease-promoting and they do so probably by producing IL-3 and IL-4 which inhibits the activation of macrophages by IFN-gamma. |
| 3 | 8288319 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) was produced in substantial amounts, but IL-3 production was minimal. |
| 4 | 7930610 | In naive mice, vaccine alone induced low levels of IL-3 and IL-5 only; vaccine plus alum induced a low IL-6 response as well. |
| 5 | 7875154 | Interleukin-3 (IL-3) increases the cellularity of the bone marrow and GM-CSF can induce mobilization of bone marrow cells into the peripheral blood. |
| 6 | 10975678 | Systemic IL-3 vaccine treatment increased intratumoral levels of intercellular adhesion molecule-1, Mac-1, EB22/5.3, tumor necrosis factor-alpha, and IL-1 mRNA in irradiated tumors, indicating that cellular infiltration was part of the response. |
| 7 | 15265893 | In contrast, a CpG-C ISS-ODN and aldrithiol-2-inactivated (AT-2) SIV induced considerable PDC activation and IFN-alpha release without needing exogenous IL-3. |
| 8 | 15864589 | In the present study, we analyze the features of type I IFNs DC generated in the presence of either IL-3 (IL-3-DC) or GM-CSF (GM-CSF-DC) and compare their capacity to respond to poly(I:C) and to subsequently trigger T-cell activation. |
| 9 | 21036386 | Amphiregulin expression by basophils in response to anti-TCR stimulation required IL-3 produced by T cells, and IL-3 alone induced high levels of amphiregulin expression by purified basophils. |
| 10 | 21036386 | Amphiregulin was expressed at much higher levels when human basophils were stimulated by IL-3 than by IgE cross-linking, whereas the opposite was true for IL-4 expression and histamine release. |
| 11 | 21106069 | Both human and mouse HPCs were expanded first in feeder culture supplemented with c-Kit ligand (KL, stem cell factor, steel factor or CD117 ligand), Flt3 ligand (fms-like tyrosine kinase 3, Flt3L, FL), thrombopoietin (TPO), IL-3, IL-6, and basic fibroblast growth factor (bFGF), and then in a second feeder culture ectopically expressing all above growth factors plus GM-CSF and IL-15.In the dual culture system, CD34+ HPCs differentiated toward DC progenitors (DCPs), which expanded more than five orders of magnitude. |