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Gene Information
Gene symbol: JAG1
Gene name: jagged 1
HGNC ID: 6188
Synonyms: AHD, AWS, HJ1, CD339
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCRN4L | 1 hits |
| 2 | CD40 | 1 hits |
| 3 | CD40LG | 1 hits |
| 4 | CD8A | 1 hits |
| 5 | HLA-A | 1 hits |
| 6 | IL6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10820273 | CD40L expression promotes Th1 cytokine responses to protein Ags and is responsible for Ig isotype switching in B cells. |
| 2 | 11290810 | Immature DC (DCimm) capture, process, and present Ags to CD4(+) lymphocytes, which reciprocally activate DCimm through CD40, and the resulting mature DC (DCmat) loose phagocytic capacity, but acquire the ability to efficiently stimulate CD8(+) lymphocytes. |
| 3 | 18221542 | The presence of CD8+T lymphocytes specific to gp100 and Melan A/MART-1 Ags was determined by ELISpot and tetramer analysis in five HLA-A*0201 patients before and after vaccination; one patient had stable elevated levels before and after vaccination; two increased their CD8 + levels, one had stable moderate and one had negligible levels. |
| 4 | 21149605 | Vaccination with protein Ags, however, often elicits only CD4(+) T cell responses without inducing Ag-specific CD8(+) T cells, as exogenous protein is primarily presented to CD4(+) T cells. |
| 5 | 21746857 | The low IL-12p40 and high IL-6 cytokine profile expressed by BRD509(pSBRT7)-stimulated DC may represent a shift toward a Th2 response, as suggested by the increased expression in Jagged-1. |
| 6 | 21908423 | Immunization of transgenic or normal mice expressing tumor-associated self Ags (Her2/neu, OVA, gp100) with a CCR4 antagonist combined with various vaccines led to the induction of effector CD8(+) T cells and partial inhibition of tumor growth expressing self Ags in both prophylactic and therapeutic settings. |