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Gene Information
Gene symbol: LAMP3
Gene name: lysosomal-associated membrane protein 3
HGNC ID: 14582
Synonyms: LAMP, TSC403, DC-LAMP, DCLAMP, CD208
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD14 | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | HLA-A | 1 hits |
| 4 | IL6 | 1 hits |
| 5 | NFKB1 | 1 hits |
| 6 | TLR2 | 1 hits |
| 7 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12824194 | The increased immune response is attributed to trafficking of the antigen chimera to the major histocompatibility class II (MHC II) compartment where LAMP is colocalized with MHC II. |
| 2 | 12824194 | Gag encoded with the translocon, transmembrane and cytoplasmic lysosomal membrane targeting sequences of LAMP, without the luminal domain, was poorly expressed, did not traffic to lysosomes or MHC II compartments of transfected cells, and elicited a limited immune response from DNA immunized mice. |
| 3 | 12824194 | This LAMP/Gag chimera with the complete LAMP protein colocalized with endogenous MHC II of transfected cells and elicited strong cellular and humoral immune responses of immunized mice as compared with the response to DNA-encoding native Gag, with a 10-fold increase in CD4+ responses, a 4- to 5-fold increase in CD8+ T-cell responses, and antibody titers of >100,000. |
| 4 | 15749921 | Moreover, CTL-mediated killing of hTERT targets was enhanced in the LAMP hTERT group, suggesting that an improved CD4+ response could augment a CTL response. |
| 5 | 19793902 | In this study, LAMPs induced the production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in a dose-dependent manner. |
| 6 | 19793902 | Furthermore, LAMP-induced NF-kappaB activation was increased in 293T cells transfected with TLR2 plasmid. |
| 7 | 19793902 | Additionally, LAMPs were shown to inhibit NF-kappaB expression by cotransfection with dominant-negative MyD88 and TLR2 plasmids. |
| 8 | 19793902 | These results suggest that M. genitalium-derived LAMPs activate NF-kappaB via TLR1, TLR2, TLR6, and CD14 in a MyD88-dependent pathway. |