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Gene Information
Gene symbol: MAP3K14
Gene name: mitogen-activated protein kinase kinase kinase 14
HGNC ID: 6853
Synonyms: NIK, HSNIK, FTDCR1B, HS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL5 | 1 hits |
| 2 | CD80 | 1 hits |
| 3 | CD86 | 1 hits |
| 4 | HLA-A | 1 hits |
| 5 | IFNG | 1 hits |
| 6 | IL12A | 1 hits |
| 7 | IL15 | 1 hits |
| 8 | IL18 | 1 hits |
| 9 | IL6 | 1 hits |
| 10 | IL8 | 1 hits |
| 11 | NFKB1 | 1 hits |
| 12 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16971487 | Here, we describe an approach to enhance immunogenicity that involves the activation of NF-kappaB by the transgenic expression of an intracellular signaling molecule, NF-kappaB-inducing kinase (NIK). |
| 2 | 16971487 | In vitro, NIK increases dendritic cell antigen presentation in allogeneic and antigen-specific T cell proliferation assays by potently activating NF-kappaB and consequently up-regulating the expression of cytokines (TNF-alpha, IL-6, IL-12, IL-15, and IL-18), chemokines [IL-8, RANTES (regulated on activation, normal T cell expressed and secreted), macrophage inflammatory protein-1alpha, monocyte chemoattractant protein-1, and monocyte chemoattractant protein-3], MHC antigen-presenting molecules (class I and II), and costimulatory molecules (CD80 and CD86). |
| 3 | 16971487 | In vivo, NIK enhances immune responses against a vector-encoded antigen and shifts them toward a T helper 1 immune response with increased IgG2a levels, T cell proliferation, IFN-gamma production, and cytotoxic T lymphocyte responses more potently than complete Freund's adjuvant, a very efficacious T helper 1-inducing adjuvant. |