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Gene Information
Gene symbol: MAPK14
Gene name: mitogen-activated protein kinase 14
HGNC ID: 6876
Synonyms: PRKM14, p38, Mxi2, PRKM15
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAMP | 1 hits |
| 2 | CYP3A4 | 1 hits |
| 3 | HMGB1 | 1 hits |
| 4 | HSPD1 | 1 hits |
| 5 | IL1B | 1 hits |
| 6 | JAK1 | 1 hits |
| 7 | MAPK1 | 1 hits |
| 8 | MUC2 | 1 hits |
| 9 | MUC5AC | 1 hits |
| 10 | NFKB1 | 1 hits |
| 11 | PPP1R3C | 1 hits |
| 12 | STAT1 | 1 hits |
| 13 | TLR2 | 1 hits |
| 14 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12686724 | Among those signaling pathways, activation of NF-kappaB leads to up-regulation of IL-1beta, IL-8 and TNF-alpha, mucin MUC2 and Toll-like receptor 2 (TLR2), whereas activation of p38 MAP kinase mediates not only up-regulation of inflammatory mediators and mucin MUC5AC but also down-regulation of TLR2. |
| 2 | 12686724 | Finally, glucocorticoids synergistically enhance NTHi-induced TLR2 expression via specific up-regulation of the MAP kinase phosphatase-1 that, in turn, leads to inactivation of p38 MAP kinase, the negative regulator for TLR2 expression. |
| 3 | 16399630 | These results suggest that CHL inhibits IL-1beta production in macrophages stimulated with LPS at transcriptional level by blocking the phosphorylation of p38 and by suppressing the activation of transcription factors, NF-kappaB, NF-IL6, and AP-1. |
| 4 | 18331466 | Pharmacological suppression of p38 or extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases with specific inhibitors failed to inhibit HSP65-induced HMGB1 release, but inhibition of c-Jun NH(2)-terminal kinase activation attenuated HMGB1 release. |
| 5 | 18579695 | Thus, these results indicate that the MEK1/2 and p38 MAPK signaling pathways play a critical role in the regulation of inducible LL-37 gene expression in A549 cells infected with M. bovis BCG. |
| 6 | 19828771 | A specific p38 MAPK inhibitor strongly inhibited V. parvula LPS-induced TNF-alpha, IL-1beta, IL-6, and IL-10. |
| 7 | 19828771 | V. parvula LPS-stimulated cytokine induction, as well as p38 MAPK activation, are TLR4-dependent features. |
| 8 | 21466820 | Pharmacologic inhibitors and a dominant-negative mutant expression plasmid were used to dissect the molecular pathway required for CYP3A4 suppression, revealing roles for Jak1 and Stat1 and eliminating the involvement of the p38 mitogen-activated and extracellular regulated kinases. |