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Gene Information
Gene symbol: MAPK8
Gene name: mitogen-activated protein kinase 8
HGNC ID: 6881
Synonyms: JNK, JNK1, SAPK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD40 | 1 hits |
| 2 | FOS | 1 hits |
| 3 | IL6 | 1 hits |
| 4 | IL8 | 1 hits |
| 5 | JUN | 1 hits |
| 6 | NOS2A | 1 hits |
| 7 | SPG7 | 1 hits |
| 8 | TLR4 | 1 hits |
| 9 | TLR7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18809662 | FlaA-induced IL-8 production in T84 cells was inhibited by the p38 inhibitor in combination with either the JNK or ERK inhibitors. |
| 2 | 18228247 | The enhanced IL-6 production was dependent upon the activity of c-Jun kinase (JNK) and cFos. |
| 3 | 18228247 | Dual stimulation through CD40 and TLR7 markedly enhanced JNK activity. |
| 4 | 18228247 | The increased level of active JNK in dual-stimulated cells was accompanied by an increase in the level of active AP-1 monomers cJun and cFos. |
| 5 | 18228247 | The stimulation of B cells through both CD40 and TLR7 therefore enhanced the production of cytokines through increased JNK signaling and AP-1 activity. |
| 6 | 21450974 | PGN stimulates the activation of all three classes of MAPKs, extracellular signal-related kinase (ERK), c-Jun N-terminal kinase (JNK), and p38(mapk) in macrophages, albeit with differential activation kinetics. |
| 7 | 21450974 | Using a selective inhibitor of JNK (SP600125) and JNK1/2 small interfering RNA (siRNA) knocked-down macrophages, it was observed that PGN-induced iNOS and NO expression is significantly inhibited. |
| 8 | 21450974 | This suggested that JNK MAPK plays an essential role in PGN-induced iNOS expression and NO production. |
| 9 | 21450974 | These results indicate that the JNK MAPK positively regulate PGN-induced iNOS and NO expression by activating NF-?B and AP-1 transcription factors, whereas the ERK pathway plays a negative regulatory role via affecting NF-?B activity. |
| 10 | 21901556 | E. coli activates TLR4, which is responsible for the activation of IL-12, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). |