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Gene Information
Gene symbol: MYD88
Gene name: myeloid differentiation primary response 88
HGNC ID: 7562
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD14 | 1 hits |
| 2 | CD274 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | CD40 | 1 hits |
| 5 | CD86 | 1 hits |
| 6 | CD8A | 1 hits |
| 7 | IFNB1 | 1 hits |
| 8 | IFNG | 1 hits |
| 9 | IL12A | 1 hits |
| 10 | IL6 | 1 hits |
| 11 | MAL | 1 hits |
| 12 | NFKB1 | 1 hits |
| 13 | NOS2A | 1 hits |
| 14 | TICAM1 | 1 hits |
| 15 | TLR2 | 1 hits |
| 16 | TLR4 | 1 hits |
| 17 | TLR9 | 1 hits |
| 18 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15760459 | BCG induced transcription and secretion of the chemokine CXCL8, by signalling through Toll-like receptors TLR2 and TLR4, in conjunction with the adaptor protein myeloid differentiation factor 88 (MyD88). |
| 2 | 16980981 | Resistance to disease required TLR4, the adaptor protein MyD88 and coreceptor MD-2 and was considerably enhanced by CD14 and the adaptor Mal. |
| 3 | 16750567 | Besides TLRs, mRNA for MyD88 and TRAF6, and nuclear translocation of NF-kappaB were enhanced that indicate their involvement in tandem in the activity of porin. |
| 4 | 17628235 | In the present study we assessed induction of CD8+ T-cell responses against an immunodominant H-2D(b)-restricted epitope of human prostate-specific antigen in C57Bl/6 (wild-type), TLR9- and MyD88-deficient mice. |
| 5 | 17978010 | To provide evidence of TLR functionality, endothelial cells were challenged with TLR ligands, and after the TLR downstream signaling, MyD88 recruitment as well as early (interleukin-8 [IL-8] release) and late immune markers (inducible nitric oxide synthase mRNA expression) were monitored. |
| 6 | 18389479 | Finally, we demonstrated in mouse and human cells that diC14-amidine liposomes use Toll-like receptor 4 to elicit both MyD88-dependent and Toll/IL-1R-containing adaptor inducing interferon IFN-beta (TRIF)-dependent responses. |
| 7 | 19620295 | When the T effector response to oral vaccination is examined we find that activated, adoptively transferred Ag-specific CD4(+) T cells accumulate in the draining lymph nodes, but fail to produce IFN-gamma, in MyD88(-/-) mice. |
| 8 | 19607952 | Local upregulation of IFN-gamma, IL-6, Cxcl9, CCL2, TNF-alpha, CD274 as well as Toll-like receptor pathway transcripts MyD88, TLR2, TLR3 and TLR9 was observed. |
| 9 | 19936231 | Primary macrophages from MyD88(-/-) and TLR2(-/-) mice were significantly impaired in the ability to secrete TNF and other pro-inflammatory cytokines upon ex vivo infection with LVS. |
| 10 | 17569868 | The inflammatory toxicity of lipopolysaccharide (LPS), a component of bacterial cell walls, is driven by the adaptor proteins myeloid differentiation factor 88 (MyD88) and Toll-interleukin 1 receptor domain-containing adapter inducing interferon-beta (TRIF), which together mediate signaling by the endotoxin receptor Toll-like receptor 4 (TLR4). |
| 11 | 21261958 | We show that the induction of a CD8+ T cell response did not require functional TLR3 or MyD88 signalling. |
| 12 | 21540455 | In addition, we elucidated the contributions of MyD88 and TRIF to priming of the NLRP3 inflammasome and demonstrated that TRIF-biased TLR4 activation by MLA was responsible for the defective production of mature IL-1?. |
| 13 | 21760953 | Taken together, our findings confirm that rEA is a potent adjuvant, triggering robust activation of the innate immune system, in a manner that is augmented by MyD88 and inhibited by TRIF; thereby unveiling the potential complexities of modulating TLR activity to augment vaccine efficacy. |
| 14 | 21173782 | Surprisingly, co-infection with rVV IL-2/rVV IL-12, but not rVV IL-2/rVV IFN-?, restored the attenuated phenotype of rVV IL-2 in MyD88(-/-) mice indicating that the IL-2/IL-12 combination promotes antiviral responses. |
| 15 | 19540594 | While upregulation of CD86 was independent of the adaptor molecule MyD88, CD40 upregulation and optimal cytokine (IL-6, TNF-alpha, IL-12p40, IL-10 and IFN-beta) production required both MyD88 and TRIF molecules. |
| 16 | 21901556 | Use of Lactobacillus species to combat UTI is now giving modern concept of modern genitourinary vaccine with the facts that it not only maintains low pH of the genital area, produces hydrogen peroxide and hinders the growth of E. coli but also activates Toll-like receptor-2 (TLR2), which produces interleukin-10 (IL-10) and myeloid differentiation factor 88 (MyD88). |
| 17 | 20880743 | The TLR4 agonist LPS activates antigen-presenting cells through myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor inducing interferon-beta (TRIF)-dependent signaling pathways, initiating CD4 T helper cell clonal expansion and differentiation. |
| 18 | 22102818 | These activities of ESAT-6 were dependent on TLR-2/MyD88 signalling and involved IL-6 and TGF-? production by dendritic cells. |