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Gene Information
Gene symbol: PDCD1LG2
Gene name: programmed cell death 1 ligand 2
HGNC ID: 18731
Synonyms: PD-L2, Btdc, PDL2, bA574F11.2, CD273, B7-DC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD274 | 1 hits |
| 2 | CD28 | 1 hits |
| 3 | CD40 | 1 hits |
| 4 | CD8A | 1 hits |
| 5 | ICOSLG | 1 hits |
| 6 | IFNG | 1 hits |
| 7 | IL10 | 1 hits |
| 8 | IL2 | 1 hits |
| 9 | PDCD1 | 1 hits |
| 10 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11283156 | B7-DC fails to bind the B7.1/2 receptors CD28 and cytotoxic T lymphocyte-associated antigen (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. |
| 2 | 19399172 | Here, FRET and co-immunoprecipitation studies show that CD40 is recruited to the multi-molecular complex by B7-DC XAb. |
| 3 | 19399172 | Importantly, the expression of CD40 was required for the overall ability of B7-DC XAb to induce anti-tumor CTL, to provide protection from a number of tumor types, and for DC(XAb) to be effective anti-tumor vaccines in vivo. |
| 4 | 19726615 | Blockade of PD-1, PD-L1, and PD-L2 using both freshly isolated and cryopreserved PBMC led to higher levels of phytohemagglutinin (PHA) and Candida-induced gamma interferon (IFN-gamma), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-alpha) with no effect on IL-10 production. |
| 5 | 20682852 | Here, we investigated whether knockdown of programmed death ligand 1 (PD-L1) and PD-L2 on monocyte-derived DCs results in improved T-cell activation. |
| 6 | 19562472 | However, in cultures from six patients, there was only a modest enhancing effect of PD-L1 and PD-L2 silencing on CD8(+) T cell proliferative responses to the DCs. |
| 7 | 21061197 | Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. |
| 8 | 21389868 | Programmed death 1 (PD-1) signaling through its ligands, PD-L1 and PD-L2, has been known to negatively regulate T-cell responses. |
| 9 | 21562114 | More importantly, ethanol-exposed DCs had reduced B7-DC and enhanced ICOS-L (inhibitory) costimulatory molecule expression. |