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Gene Information
Gene symbol: PIK3CA
Gene name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
HGNC ID: 8975
Synonyms: PI3K
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DUSP1 | 1 hits |
| 2 | GATA3 | 1 hits |
| 3 | MAPK1 | 1 hits |
| 4 | MAPK3 | 1 hits |
| 5 | NFKB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16641451 | Herein, we show that SAG induces extracellular signal-regulated kinase 1 (ERK-1) and ERK-2 phosphorylation through phosphoinositide 3-kinase (PI3K), protein kinase C, and Ras activation and p38 mitogen-activated protein kinase (MAPK) phosphorylation through PI3K and Akt activation. |
| 2 | 16826166 | The ERK-independent activation of p70S6 kinase involves phosphorylation at threonine-389, threonine-421/serine-424, and serine-411 sites with intermediate phosphatidylinositol 3 kinase and protein kinase C-zeta activation. |
| 3 | 19017952 | CD28-mediated signaling through PI3K results in the recruitment of protein kinase C-theta (PKCtheta) to the cSMAC, activation of NF-kappaB, and up-regulation of IL-2 transcription. |
| 4 | 20696860 | Thus, TCR signaling through PI3K may play a critical role in Th2 differentiation by the specific enhancement of GATA-3 translation. |
| 5 | 21098227 | These data suggest that infection by LVS restrains the TLR2-triggered proinflammatory response via parallel activation of PI3K, leading to enhanced MKP-1 expression, accelerated deactivation of MAPKs, and suppression of proinflammatory cytokine production. |