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Gene Information

Gene symbol: RIPK1

Gene name: receptor (TNFRSF)-interacting serine-threonine kinase 1

HGNC ID: 10019

Synonyms: RIP

Related Genes

#	Gene Symbol	Number of hits
1	CASP8	1 hits
2	NFKB1	1 hits
3	ZBP1	1 hits

Related Sentences

#	PMID	Sentence
1	21368762	Casp8 suppresses RIP3-RIP1 (also known as RIPK3-RIPK1) kinase complex-dependent necroptosis that follows death receptor activation as well as a RIP3-dependent, RIP1-independent necrotic pathway that has emerged as a host defence mechanism against murine cytomegalovirus.
2	18941233	In this study, induction of NF-kappaB is shown to depend on the adaptor receptor-interacting protein kinase (RIP)1, acting via a RIP homotypic interaction motif (RHIM)-dependent interaction with DAI.
3	18941233	DAI binds to and colocalizes with endogenous RIP1 at characteristic cytoplasmic granules.
4	18941233	Suppression of RIP1 expression by RNAi abrogates NF-kappaB activation as well as IFNbeta induction by immunostimulatory DNA.
5	18941233	The role of DAI in activation of NF-kappaB in response to immunostimulatory DNA appears to be analogous to sensing of dsRNA by TLR3 in that both pathways involve RHIM-dependent signaling that is mediated via RIP1, reinforcing a central role for this adaptor in innate sensing of intracellular microbes.