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Gene Information
Gene symbol: SH2D1A
Gene name: SH2 domain containing 1A
HGNC ID: 10820
Synonyms: XLP, MTCP1, DSHP, XLPD, EBVS, SAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | IL4 | 1 hits |
| 3 | SLAMF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16788096 | The human genetic disease X-linked lymphoproliferative disease (XLP), which is caused by mutations in SH2D1A/SAP that encode SLAM-associated protein (SAP), is characterized by an inability to control Epstein-Barr virus (EBV) and hypogammaglobulinemia. |
| 2 | 20525889 | We further demonstrate that SLAM (Slamf1, CD150), a surface receptor that uses SAP signaling, is specifically required for IL-4 production by GC T(FH) cells. |
| 3 | 20525889 | These data illustrate complexities of SAP-dependent SLAM family receptor signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T cells but not in T(FH) cell and GC T(FH) cell differentiation. |