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Gene Information
Gene symbol: SOCS1
Gene name: suppressor of cytokine signaling 1
HGNC ID: 19383
Synonyms: SOCS-1, SSI-1, JAB, TIP3, Cish1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | FAS | 1 hits |
| 4 | FASLG | 1 hits |
| 5 | IFNB1 | 1 hits |
| 6 | IL15RA | 1 hits |
| 7 | IL17A | 1 hits |
| 8 | IL6 | 1 hits |
| 9 | LEPR | 1 hits |
| 10 | STAT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16381597 | We found that SOCS1-silenced DCs broadly induced enhanced HIV-1 envelope (Env)-specific CD8+ cytotoxic T lymphocytes and CD4+ T helper cells, as well as antibody responses, in mice. |
| 2 | 20592105 | Indeed, leptin receptor mRNA expression was significantly reduced in the lungs of obese mice, whereas suppressor of cytokine signaling (Socs)1 and Socs3 mRNA expression were increased. |
| 3 | 20080139 | Gene knockdown of the suppressor of cytokine signaling 1 (SOCS1), a negative-feedback regulator of the immune response in BMDCs resulted in an enhanced phosphorylation of STAT1, and the production of proinflammatory cytokines. |
| 4 | 21479379 | SOCS1-silencing in DCs could prevent immune tolerance by inhibiting Fas and Fas-L expression, induced by an increase in IL-12p70 and IL-6 production. |
| 5 | 21479379 | In addition, in 2x106 SOCS1-silenced DC/TRP2 immunized mice, higher levels of IL-12p70 and IFN-? and lower IL-17 production may inhibit tumor angiogenesis and therefore assist in breaking immune tolerance. |
| 6 | 20826039 | Gene knockdown of the suppressor of cytokine signaling 1 (SOCS1), a negative-feedback regulator of the immune response in BMDCs resulted in an enhanced phosphorylation of STAT1, and the production of proinflammatory cytokines. |
| 7 | 18222020 | In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and antigen-specific responses, as measured by ELISPOT, CTL assays, serum ELISAs, and T-cell proliferation assays. |
| 8 | 18222020 | Bone marrow-derived dendritic cells in which SOCS1 was downregulated expressed increased levels of surface IL-15Ra and thymic leukemia (TL) antigen, both of which support memory cell development. |
| 9 | 21992229 | The expression levels of interferon beta 1 (Ifnb1) were increased significantly in Isg15, Socs1 or Socs3 siRNA treated cells. |