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Gene Information

Gene symbol: SPG7

Gene name: spastic paraplegia 7 (pure and complicated autosomal recessive)

HGNC ID: 11237

Synonyms: CAR, SPG5C

Related Genes

#	Gene Symbol	Number of hits
1	CD80	1 hits
2	CD86	1 hits
3	FOS	1 hits
4	JUN	1 hits
5	MAPK1	1 hits
6	MAPK8	1 hits
7	NOS2A	1 hits
8	TLR2	1 hits

Related Sentences

#	PMID	Sentence
1	19278729	Stimulation with TNF, S. gordonii, PGN, LTA, or LP all resulted in increased surface expression of MHCII, CD80, and CD86, compared to unstimulated BM-DCs.
2	21188584	Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation.
3	21450974	The objectives of this study were to examine the roles of mitogen-activated protein kinases (MAPKs) and transcription factors (nuclear factor-?B [NF-?B] and activating protein 1 [AP-1]) in peptidoglycan (PGN)-induced iNOS expression and NO production in macrophages.
4	21450974	PGN stimulates the activation of all three classes of MAPKs, extracellular signal-related kinase (ERK), c-Jun N-terminal kinase (JNK), and p38(mapk) in macrophages, albeit with differential activation kinetics.
5	21450974	Using a selective inhibitor of JNK (SP600125) and JNK1/2 small interfering RNA (siRNA) knocked-down macrophages, it was observed that PGN-induced iNOS and NO expression is significantly inhibited.
6	21450974	This suggested that JNK MAPK plays an essential role in PGN-induced iNOS expression and NO production.
7	21450974	In contrast, inhibition of the ERK pathway using PD98059 dose dependently enhanced PGN-induced iNOS expression and NO production.
8	21450974	These results indicate that the JNK MAPK positively regulate PGN-induced iNOS and NO expression by activating NF-?B and AP-1 transcription factors, whereas the ERK pathway plays a negative regulatory role via affecting NF-?B activity.