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Gene Information
Gene symbol: STAT3
Gene name: signal transducer and activator of transcription 3 (acute-phase response factor)
HGNC ID: 11364
Synonyms: APRF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2 | 1 hits |
| 2 | BCL2L1 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | CD8A | 1 hits |
| 5 | IFNG | 1 hits |
| 6 | IL10 | 1 hits |
| 7 | IL17C | 1 hits |
| 8 | IL6 | 1 hits |
| 9 | NPR1 | 1 hits |
| 10 | TBX21 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20346983 | CTLs cultured with STAT3-deficient APCs demonstrated a stronger proliferative response and produced increased amounts of IFN-gamma and TNF-alpha, all of which have been shown to be diminished in tumor-tolerized CD8 T cells. |
| 2 | 21257966 | We further revealed that IL-21 promoted CD8 T cell survival in a mechanism dependent on activation of the STAT1 and STAT3 pathways and subsequent upregulation of the prosurvival molecules Bcl-2 and Bcl-x(L). |
| 3 | 21527558 | In vaccinated mice, silencing STAT3 increased the proliferation and granzyme B levels of intratumoral CD4(+) and CD8(+) T cells. |
| 4 | 18670213 | IL-15 predominantly activated STAT5, whereas IL-21 activated STAT5 and STAT3. |
| 5 | 21219617 | NPRA is associated with TLR-2, SOCS3 and STAT3, and inhibiting NPRA alters expression of IL-6, IL-10 and TGF-?, but not IL-12. |
| 6 | 21806885 | The expression of T-bet mRNA has negative correlation with GATA-3 mRNA (r=-0.696), the expression of STAT-3 mRNA has correlation with T-bet mRNA and GATA-3 mRNA(r=-0.767, 0.772), P<0.05. |
| 7 | 21985363 | We show that soluble CD40L consistently induces the phosphorylation of nuclear factor (NF)-?B p65 but not of STAT3, while IL-10 induces the phosphorylation of STAT3 but not of NF-?B p65. |
| 8 | 21985363 | Finally, the STAT3 pathway was directly activated by IL-10, while IL-6, the main cytokine otherwise known for activating the STAT3 pathway, did not appear to be involved in IL-10-induced-STAT3 activation. |