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Gene Information
Gene symbol: TLR3
Gene name: toll-like receptor 3
HGNC ID: 11849
Synonyms: CD283
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL2 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | CXCL10 | 1 hits |
| 4 | CXCL9 | 1 hits |
| 5 | IFIH1 | 1 hits |
| 6 | IFNA1 | 1 hits |
| 7 | IFNG | 1 hits |
| 8 | IL12A | 1 hits |
| 9 | IL6 | 1 hits |
| 10 | TICAM1 | 1 hits |
| 11 | TLR2 | 1 hits |
| 12 | TLR4 | 1 hits |
| 13 | TLR9 | 1 hits |
| 14 | TNF | 1 hits |
| 15 | UBASH3B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16904966 | In the current study we demonstrate that signaling through toll-like receptor (TLR) 8, but not TLR3, TLR2, or TLR4, provides a priming signal to myeloid-derived DC for high IL-12 p70 heterodimer production. |
| 2 | 18490712 | Here we show that treatment of murine fetal thymic organ cultures (FTOCs) with TLR3 or TLR7 ligands induced rapid expression of IFN-alpha and -beta mRNA, hallmarks of acute and chronic viral infections. |
| 3 | 19515829 | Our results indicate that infection with amplicons triggered an interferon (IFN)-regulatory factors 3 and 7 (IRF3/7)-dependent antiviral response, rendered the cells resistant to vesicular stomatitis virus infection and induced significant changes in the pattern of cellular gene expression, including the upregulation of Toll-like receptor 3 (TLR3), IRF7 and IFN-stimulated genes (ISGs). |
| 4 | 19607952 | Local upregulation of IFN-gamma, IL-6, Cxcl9, CCL2, TNF-alpha, CD274 as well as Toll-like receptor pathway transcripts MyD88, TLR2, TLR3 and TLR9 was observed. |
| 5 | 19995959 | MDA5 and TLR3 activated NK cells indirectly through accessory cells and induced the distinct stimulatory cytokines interferon-alpha and interleukin-12, respectively. |
| 6 | 19995959 | Interestingly, multiple accessory cells were implicated, with MDA5 acting primarily in stromal cells and TLR3 predominantly in hematopoietic cells. |
| 7 | 20068181 | We took advantage of two TLR3-expressing tumor models that produced large amounts of CCL5 (a CCR5 ligand) and CXCL10 (a CXCR3 ligand) in response to type I IFN and poly(A:U), both in vitro and in vivo. |
| 8 | 20631129 | The TLR3 ligand poly(I:C) suppressed Gag-specific cellular immune responses, whereas the TLR4 ligands lipopolysaccharide and monophosphoryl lipid A substantially augmented the magnitude and functionality of these responses by a MyD88- and TRIF-dependent mechanism. |
| 9 | 19027047 | We have recently reported that the toll-like receptor 3 (TLR3) agonist poly(I:C) induces adjuvant effects to post vaccination CD8+ T cells responses through rapid induction of innate mediators, including NK cells, macrophages, dendritic cells (DCs), and inflammatory cytokines. |
| 10 | 19027047 | However, whether this TLR3 agonist directly targets CD8+ T cells needs to be carefully investigated. |
| 11 | 19027047 | These results suggest that CD8+ T cells can be activated by triggering their TLR3. |
| 12 | 21261958 | We show that the induction of a CD8+ T cell response did not require functional TLR3 or MyD88 signalling. |
| 13 | 19054578 | We demonstrated that LAB induced strong TLR2-expressing APC responses in blood and spleen, HRV induced a TLR3 response in spleen, and TLR9 responses were induced by either HRV (in spleen) or LAB (in blood). |