Ignet

Gene Information

Gene symbol: TLR4

Gene name: toll-like receptor 4

HGNC ID: 11850

Synonyms: hToll, CD284, TLR-4

Related Genes

#	Gene Symbol	Number of hits
1	ADAM11	1 hits
2	CAMP	1 hits
3	CCL7	1 hits
4	CD14	1 hits
5	CD4	1 hits
6	CD40	1 hits
7	CD80	1 hits
8	CD86	1 hits
9	CTAG1B	1 hits
10	CXCL10	1 hits
11	DEFB1	1 hits
12	HLA-A	1 hits
13	HSPA1A	1 hits
14	IFNA1	1 hits
15	IFNG	1 hits
16	IL12A	1 hits
17	IL1B	1 hits
18	IL6	1 hits
19	JUN	1 hits
20	MAPK1	1 hits
21	MAPK8	1 hits
22	MYD88	1 hits
23	PIK3CG	1 hits
24	TICAM1	1 hits
25	TLR2	1 hits
26	TLR3	1 hits
27	TLR5	1 hits
28	TLR9	1 hits
29	TNF	1 hits
30	UBASH3B	1 hits

Related Sentences

#	PMID	Sentence
1	21900253	NY-ESO-1 binding to immature dendritic cells was dependent on its polymeric structure and involved Toll-like receptor-4 (TLR4) on the surface of immature dendritic cells in mouse and human.
2	21900253	Gene gun-delivered plasmid encoding the wild-type NY-ESO-1 readily induced T cell-dependent antibody (Ab) responses in wild-type C57BL/10 mice but not TLR4-knock-out C57BL/10ScNJ mice.
3	14530357	In contrast, MDCs, which express TLR3, TLR4, and TLR7, responded to poly(I:C), LPS, and imidazoquinolines with phenotypic maturation and high production of IL-12 p70 without producing detectable IFN-alpha.
4	16426010	TLR5 expression is down-regulated in vivo during acute and chronic DSS-induced colitis, in contrast to the expression of TLR2, TLR4, and CD14.
5	16904966	In the current study we demonstrate that signaling through toll-like receptor (TLR) 8, but not TLR3, TLR2, or TLR4, provides a priming signal to myeloid-derived DC for high IL-12 p70 heterodimer production.
6	16980981	Resistance to disease required TLR4, the adaptor protein MyD88 and coreceptor MD-2 and was considerably enhanced by CD14 and the adaptor Mal.
7	17049413	Among other receptors, toll like receptor (TLR)-2 and TLR-4 have been suggested to be involved in HSP70-mediated signalling.
8	17974997	Whereas neither iCD40 nor TLR-4 signaling alone led to high levels of interleukin (IL)-12p70 and IL-6, using iCD40 in combination with lipopolysaccharide (LPS) or monophosphoryl lipid A led to strongly synergistic production of both.
9	18208411	In accordance with the TLR expression levels, DCs generated from both AML patients and HVs responded to the known microbial ligands peptidoglycan (PGN) and lipoteichoic acid for TLR-2 and LPS as ligand for TLR-4, by producing TNF-alpha and IL-6.
10	19828771	Pretreatment of cells with a TLR4 antagonist significantly reduced TNF-alpha and IL-6 production in PBMC stimulated with either Veillonella or Escherichia coli LPS.
11	19889459	Furthermore, upon exposure of dendritic cells from HLA-A*0201-transgenic mice to the chimeric particle, the expression of CD86, HLA-A02, TLR4 and MHC class II was increased.
12	19899953	For example, TLR4 is activated by lipopolysaccharide (LPS), whereas TLR9 responds to microbial DNA (CpGs).
13	20495560	ROS orchestrated T(H)2 responses by inducing oxidized lipids that triggered the induction of thymic stromal lymphopoietin (TSLP) by epithelial cells mediated by Toll-like receptor 4 (TLR4) and the adaptor protein TRIF; by suppressing production of the T(H)1-inducing molecules IL-12 and CD70 in lymph node DCs; and by inducing the DC-derived chemokine CCL7, which mediated recruitment of IL-4(+) basophils to the lymph node.
14	20631129	The TLR3 ligand poly(I:C) suppressed Gag-specific cellular immune responses, whereas the TLR4 ligands lipopolysaccharide and monophosphoryl lipid A substantially augmented the magnitude and functionality of these responses by a MyD88- and TRIF-dependent mechanism.
15	20719993	In these cells, stimulation of TLR3 and TLR4 by their ligands suppressed HIV-1 expression partly through type I interferon (IFN).
16	20719993	The bacteria with suppressive effects preferentially stimulated TLR4, whereas the ones with enhancing effects stimulated TLR2.
17	21049021	LL-37 also inhibited the ability of meningococcal CPS to induce nitric oxide release, as well as TNF? and CXCL10 (IP-10) release from TLR4-sufficient and TLR4-deficient murine macrophages.
18	21112482	After BMDCs were activated by E. coli LLO/OVA via TLR4, NOD1 receptor and NF-?B signalling pathway, the expression of their surface molecules including MHC class I, MHC class II, CD40, CD80 and CD86 significantly up-regulated; the secretion of IL-12 and IFN-? increased also.
19	21203418	Together our data demonstrate that TLR4 activation contributes to the immunogenicity of the N. meningitidis OMV vaccine and the whole cell pertussis vaccine, but that TLR2 activation is not required.
20	21236236	The T.g.HSP70 gene vaccine also limited cyst number in the brains of WT, TLR2-deficient and TRIF-deficient mice, but not TLR4-deficient mice at a chronic phase of toxoplasmosis.
21	19641135	These two receptor types appeared functionally interdependent, as indicated by the finding that tlr2 and tlr4 knockout decreases HSP70 binding in double-knockout DC and reduces SREC-1 expression.
22	21540455	Signaling downstream of TLR4 is mediated by the adaptor proteins TRIF [Toll-interleukin-1 (IL-1) receptor (TIR) domain-containing adaptor-inducing interferon-?], which is required for adaptive immune outcomes, and MyD88 (myeloid differentiation marker 88), which is responsible for many proinflammatory effects.
23	21540455	In addition, we elucidated the contributions of MyD88 and TRIF to priming of the NLRP3 inflammasome and demonstrated that TRIF-biased TLR4 activation by MLA was responsible for the defective production of mature IL-1?.
24	20653102	Evidence is provided that the induction of a serum IgG2a (Th1-type) anti-SBR antibody response involved TLR2 signaling, whereas the anti-Salmonella response involved signaling through TLR4.
25	21368092	HBHA induced DC maturation in a TLR4-dependent manner, elevating expression of the surface molecules CD40, CD80, and CD86, MHC classes I and II and the proinflammatory cytokines IL-6, IL-12, IL-1?, TNF-?, and CCR7, as well as stimulating the migratory capacity of DCs in vitro and in vivo.
26	21645538	Inhibition of PI3K enhanced induction of pro-inflammatory cytokines, by TLR-2/TLR-1, TLR-2/TLR-6 and TLR-4 ligands as well as heat killed S. pneumoniae (HKSP).
27	21865417	The demonstration of Toll-like receptor 4 (TLR4) and NF-?B expression in hVECs and the observations of RVFHb?P suppression of human ?-defensin-1 (hBD1) mRNA expression further support the hypothesis of a genomic activity of RVFHb?P.
28	21901556	E. coli activates TLR4, which is responsible for the activation of IL-12, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK).
29	20880743	The TLR4 agonist LPS activates antigen-presenting cells through myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor inducing interferon-beta (TRIF)-dependent signaling pathways, initiating CD4 T helper cell clonal expansion and differentiation.