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Gene Information
Gene symbol: TLR5
Gene name: toll-like receptor 5
HGNC ID: 11851
Synonyms: TIL3, SLEB1, FLJ10052, MGC126430, MGC126431
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD14 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | IL8 | 1 hits |
| 5 | NLRC4 | 1 hits |
| 6 | TLR2 | 1 hits |
| 7 | TLR4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21872305 | The immunomodulating properties of rflaA plus rOVA and rflaA:OVA were investigated by means of DC-T-cell coculture with CD4(+) T cells from OVA-T-cell receptor transgenic or OVA/alum-immunized mice. rflaA:OVA was applied as a prophylactic and therapeutic vaccine in a murine model of intestinal allergy. rflaA:OVA induced upregulation of TLR5 and dose-dependent IL-6 and IL-10 secretion by myeloid dendritic cells. |
| 2 | 16369026 | FlaB bound directly to human TLR5 expressed on cultured epithelial cells and consequently induced NF-kappaB and interleukin-8 activation. |
| 3 | 16426010 | TLR5 expression is down-regulated in vivo during acute and chronic DSS-induced colitis, in contrast to the expression of TLR2, TLR4, and CD14. |
| 4 | 16426010 | Finally, IFN-gamma may be involved in down-regulating TLR5 expression. |
| 5 | 18325643 |
Heterozygous variants for SNPs in TLR5 (rs5744174) and TLR6 (rs5743818) were associated with higher levels of (p |
| 6 | 18809662 | Bacterial flagellins are known to induce IL-8 production through Toll-like receptor 5 (TLR5). |
| 7 | 18809662 | Since the V. cholerae genome encodes five distinct flagellin proteins, FlaA to FlaE, with homology to conserved TLR5 recognition regions of Salmonella FliC, we hypothesized that V. cholerae flagellins may contribute to IL-8 induction through TLR5 and mitogen-activated protein kinase (MAPK) signaling. |
| 8 | 18809662 | Each purified recombinant V. cholerae flagellin induced IL-8 production in T84 intestinal epithelial cells and also induced nuclear factor kappa B (NF-kappaB) activation in HEK293T/TLR5 transfectants, which was blocked by cotransfection with a TLR5 dominant-negative construct, demonstrating TLR5 specificity. |
| 9 | 18809662 | Supernatants derived from Delta flaAC and Delta flaEDB mutants induced IL-8 production in HT-29 intestinal epithelial cells and in HEK293T cells overexpressing TLR5, whereas Delta flaABCDE supernatants induced significantly less IL-8 production, demonstrating the contribution of multiple flagellins in IL-8 induction. |
| 10 | 20965571 | Dose-dependent IL-8 secretion from transgenic HEK 293 cells confirmed binding of rflaA and rflaA:Ova molecules to human and murine TLR5. |
| 11 | 21072873 | Thus, we examined the ability of flagellin to induce cytokines and elicit/promote murine antibody responses upon deletion of the flagellin receptors TLR5 and/or NLRC4 (also referred to as IPAF) using a prime/boost regimen. |