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Gene Information
Gene symbol: TLR9
Gene name: toll-like receptor 9
HGNC ID: 15633
Synonyms: CD289
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL2 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | CXCL9 | 1 hits |
| 4 | IFNA1 | 1 hits |
| 5 | IFNG | 1 hits |
| 6 | IL6 | 1 hits |
| 7 | IRF7 | 1 hits |
| 8 | MAPK1 | 1 hits |
| 9 | MYD88 | 1 hits |
| 10 | PAM | 1 hits |
| 11 | TLR2 | 1 hits |
| 12 | TLR3 | 1 hits |
| 13 | TLR4 | 1 hits |
| 14 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16972041 | Together with CpG ODNs that induce Toll-like receptor 9(+) (TLR9(+)) plasmacytoid dendritic cells to release type I IFN-alpha and -beta will reactivate the inhibited Th1 cells and the antiviral cytotoxic T leukocytes. |
| 2 | 17628235 | In the present study we assessed induction of CD8+ T-cell responses against an immunodominant H-2D(b)-restricted epitope of human prostate-specific antigen in C57Bl/6 (wild-type), TLR9- and MyD88-deficient mice. |
| 3 | 18208411 | AML-DCs and HV-DCs strongly expressed TLR-2 and TLR-4, while TLR-9 was expressed at a lower level in both groups. |
| 4 | 19607952 | Local upregulation of IFN-gamma, IL-6, Cxcl9, CCL2, TNF-alpha, CD274 as well as Toll-like receptor pathway transcripts MyD88, TLR2, TLR3 and TLR9 was observed. |
| 5 | 19899953 | For example, TLR4 is activated by lipopolysaccharide (LPS), whereas TLR9 responds to microbial DNA (CpGs). |
| 6 | 21134826 | First, HBV DNA can be recognized by DCs through toll-like receptor 9 (TLR9) which activates the NF-?B signal pathway and p38 MAPK to up-regulate the expression of interferon (IFN) regulatory factor 7 (IRF-7) in a manner independent of type I IFN signaling, resulting in secretion of type I IFN and inflammatory cytokines, and induction of DC maturation and the adaptive immune response. |
| 7 | 19273561 | Finally, costimulation of BMDCs with YGPs and either the TLR9 ligand, CpG, or the TLR2/1 ligand, Pam(3)CSK(4), resulted in upregulated secretion of IL-1alpha and IL-10 and downregulated secretion of IL-1beta, IL-6, and IFN-gamma-inducible protein 10 but had no significant effects on IL-12p40, keratinocyte-derived chemokine, monocyte chemotactic protein 1, or macrophage inflammatory protein alpha, compared with the TLR ligand alone. |
| 8 | 19054578 | We demonstrated that LAB induced strong TLR2-expressing APC responses in blood and spleen, HRV induced a TLR3 response in spleen, and TLR9 responses were induced by either HRV (in spleen) or LAB (in blood). |
| 9 | 21884170 | For example, TLR9 has evolved to detect CpG DNA commonly found in bacteria and viruses and to initiate the production of IFN and other cytokines. |