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Gene Information

Gene symbol: TNFRSF9

Gene name: tumor necrosis factor receptor superfamily, member 9

HGNC ID: 11924

Synonyms: CD137, 4-1BB

Related Genes

#	Gene Symbol	Number of hits
1	CD274	1 hits
2	CD28	1 hits
3	CD4	1 hits
4	CD8A	1 hits
5	CSF2	1 hits
6	CTLA4	1 hits
7	IL12A	1 hits
8	KLRG1	1 hits

Related Sentences

#	PMID	Sentence
1	11937526	In conclusion, our data reveal that the 4-1BB-mediated survival signal is positioned downstream of Ag-specific TCR triggering and CD28-dependent costimulation of naive CTL.
2	12590704	Stimulation of 4-1BBL on DCs with 4-1BB-Fc or with 4-1BB-transfected Jurkat cells resulted in acquisition of capacity for the immature DCs to produce interleukin-12 (IL-12).
3	21559358	Antibodies which block CTLA-4 or which activate 4-1BB can promote the rejection of some murine tumors, but fail to cure poorly immunogenic tumors like B16 melanoma as single agents.
4	21559358	We find that combining ?CTLA-4 and ?4-1BB antibodies in the context of a Flt3-ligand, but not a GM-CSF, based B16 melanoma vaccine promoted synergistic levels of tumor rejection. 4-1BB activation elicited strong infiltration of CD8+ T-cells into the tumor and drove the proliferation of these cells, while CTLA-4 blockade did the same for CD4+ effector T-cells.
5	21559358	Anti 4-1BB treatment, with or without CTLA-4 blockade, induced approximately 75% of CD8+ and 45% of CD4+ effector T-cells in the tumor to express the killer cell lectin-like receptor G1 (KLRG1).
6	21571303	In the 20 ?g 4-1BB ligation group, significant induction of CD3(+)CD8(+) T cells was observed without toxicity to CD3(+)CD4(+) T cells.
7	21742975	We tested the effect of combining PD ligand 1 (PD-L1) blockade with an agonistic regimen that induces 4-1BB costimulation during chronic LCMV infection.