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Gene Information

Gene symbol: TNFSF14

Gene name: tumor necrosis factor (ligand) superfamily, member 14

HGNC ID: 11930

Synonyms: LIGHT, LTg, HVEM-L, CD258

Related Genes

#	Gene Symbol	Number of hits
1	CCL21	1 hits
2	CD80	1 hits
3	CD8A	1 hits
4	IFNG	1 hits
5	LTB	1 hits

Related Sentences

#	PMID	Sentence
1	20418899	LIGHT-modified A20 cells effectively stimulated the proliferation of T lymphocytes and interferon (IFN)-gamma production in vitro.
2	20418899	This adenovirus-mediated LIGHT therapy induced substantial splenic natural killer (NK) and cytotoxic T lymphocyte (CTL) activity, enhanced tumor infiltration by inflammatory cells and increased chemokine expression of CC chemokine ligand 21 (CCL21), IFN-inducible protein-10 (IP-10) and monokine induced by IFN-gamma (Mig) from tumor tissues.
3	20406970	Intraprostatic injection of LIGHT-expressing tumor cells increased the proportion of CD8+ T cells with functional capacity within the cancerous gland.
4	20460520	LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tissues inside tumor sites and recruits naïve T cells into the tumor.
5	20460520	Our data show that forced expression of LIGHT in tumors results in an increase in expression of IFNgamma and chemoattractant cytokines such as interleukin-1a, MIG, and macrophage inflammatory protein-2 within the tumor and that this tumor microenvironment correlates with an increase in frequency of tumor-infiltrating CD8(+) T cells.
6	21394107	We tested in Her2/neu+ breast cancer and HPV-16 E6/E7+ cervical cancer mouse models, whether intratumoral expression of immunostimulatory proteins (ISPs), for example, recombinant antibodies (?CTLA-4, ?CD137, ?CD3), cyto/chemokines (IL-15, LIGHT, mda-7) and costimulatory ligands (CD80), through adenovirus(Ad)-mediated gene transfer would overcome resistance.