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Gene Information

Gene symbol: ZBP1

Gene name: Z-DNA binding protein 1

HGNC ID: 16176

Synonyms: dJ718J7.3, DLM1, DLM-1, DAI

Related Genes

#	Gene Symbol	Number of hits
1	IFNG	1 hits
2	IRF3	1 hits
3	KRR1	1 hits
4	NFKB1	1 hits
5	RIPK1	1 hits
6	RIPK3	1 hits

Related Sentences

#	PMID	Sentence
1	18941233	DNA-dependent activator of IFN regulatory factors (IRF; DAI, also known as ZBP1 or DLM-1) is a cytosolic DNA sensor that initiates IRF3 and NF-kappaB pathways leading to activation of type I IFNs (IFNalpha, IFNbeta) and other cytokines.
2	18941233	In this study, induction of NF-kappaB is shown to depend on the adaptor receptor-interacting protein kinase (RIP)1, acting via a RIP homotypic interaction motif (RHIM)-dependent interaction with DAI.
3	18941233	DAI binds to and colocalizes with endogenous RIP1 at characteristic cytoplasmic granules.
4	18941233	DAI also interacts with RIP3 and this interaction potentiates DAI-mediated activation of NF-kappaB, implicating RIP3 in regulating this RHIM-dependent pathway.
5	18941233	The role of DAI in activation of NF-kappaB in response to immunostimulatory DNA appears to be analogous to sensing of dsRNA by TLR3 in that both pathways involve RHIM-dependent signaling that is mediated via RIP1, reinforcing a central role for this adaptor in innate sensing of intracellular microbes.
6	19846511	Moreover, we identify Z-DNA binding protein 1 (ZBP1) as being essential for IRF3 activation and interferon beta expression triggered by HCMV, as well as being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion.
7	19846511	ZBP1 was recently identified as a cytosolic pattern recognition receptor of double-stranded DNA, and thus, we propose a model for HCMV-mediated IRF3 activation that involves HCMV-associated DNA as the principal innate immune-activating pathogen-associated molecular pattern.