Ignet

Gene Information

Gene symbol: ABCA1

Gene name: ATP-binding cassette, sub-family A (ABC1), member 1

HGNC ID: 29

Synonyms: TGD

Related Genes

#	Gene Symbol	Number of hits
1	ABCG1	1 hits
2	ACOX1	1 hits
3	CBR1	1 hits
4	CD36	1 hits
5	CNBP	1 hits
6	CYP27A1	1 hits
7	GLI2	1 hits
8	IL4	1 hits
9	INS	1 hits
10	LPAL2	1 hits
11	MPO	1 hits
12	MSR1	1 hits
13	NR1H3	1 hits
14	NRG1	1 hits
15	PPARA	1 hits
16	PPARG	1 hits
17	SCD	1 hits
18	SOD1	1 hits
19	SOD2	1 hits
20	UCP1	1 hits

Related Sentences

#	PMID	Sentence
1	11712406	Recently, it was demonstrated that pioglitazone is also an agonist of PPAR-alpha, which plays a central role in lipid metabolism through enhancing the synthesis of apo AI, apo AII and reverse cholesterol transporters, such as fatty acid transporter molecules, and SR-B1 and ABCA1 reverse cholesterol transport receptors.
2	12923232	The LXR ligand T0901317 elevates ATP binding cassette transporter A1 (ABCA1) and HDL levels in animal models and induces moderate lipogenesis through upregulation of sterol regulatory element binding protein 1c (SREBP1c).
3	14967823	These results suggest that LXR/RXR ligands generate ABCA1-destabilizing monounsaturated fatty acids from their saturated precursors by activating SCD.
4	15983222	The ATP-binding cassette transporter A1 (ABCA1) is an atheroprotective cell protein that mediates cholesterol transport from cells to apolipoprotein (apo) A-I, the major protein in HDL.
5	18849545	Conclusions: We propose that ritonavir induces ABCA1 expression in THP-1 macrophages through LXRalpha.
6	18849545	The increase in ABCA1 and other cholesterol efflux mediators, such as CYP27, may compensate CD36 induction.
7	20811644	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.
8	20728534	Under both conditions, knockdown of CBR1 by specific siRNA increased ?-cell apoptosis, expression of lipogenic enzymes (such as ACC, FAS, and ABCA1), intracellular lipid accumulation, oxidative stress, ER stress, and nuclear SREBP1c, but decreased glucose-stimulated insulin secretion.
9	20212278	Cholesterol efflux to apoA-I and HDL3 was impaired in ABCA1(-/-) and SR-BI(-/-) adipocytes, respectively, with no effect observed in ABCG1(-/-) adipocytes.
10	20067955	Abnormal cellular cholesterol handling in islets may contribute to beta-cell dysfunction in type 2 diabetes. beta-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular cholesterol homeostasis and impaired insulin secretion in mice.
11	21330603	Lipid-free apoA-I mediated its effects on Nox2, SOD1, and SOD2 via ABCA1.
12	19644050	Heregulin-beta(1), but not heregulin-alpha, significantly reduced acetylated low-density lipoprotein-induced cholesterol ester accumulation in primary cultured human monocyte-derived macrophages by reducing SR-A and ACAT1 expression and by increasing ABCA1 expression at both mRNA and protein levels.
13	20158099	Recent studies reported that PPARgamma agonists involve in lipid metabolism through regulating genes including lipoprotein lipase, CD36, and ABCA1.
14	21823057	AGE decreased ABCA1 and ABCG1 mRNA levels, and subsequently reduced cholesterol efflux from THP-1 cells, which was prevented by GGPP.
15	21900603	In isolated macrophages, ER? was necessary for repression of inflammation, maintenance of oxidative metabolism, IL-4-mediated induction of alternative activation, full phagocytic capacity in response to LPS, and oxidized LDL-induced expression of ApoE and Abca1.
16	21501700	Here, we describe how MPO-dependent chlorination impairs the ability of apolipoprotein A-I (apoA-I), HDL's major protein, to transport cholesterol by the ATP-binding cassette transporter A1 (ABCA1) pathway.