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Gene Information

Gene symbol: ABCB1

Gene name: ATP-binding cassette, sub-family B (MDR/TAP), member 1

HGNC ID: 40

Synonyms: P-gp, CD243, GP170, ABC20

Related Genes

#	Gene Symbol	Number of hits
1	NFKB1	1 hits
2	NOS2A	1 hits
3	PRKCA	1 hits

Related Sentences

#	PMID	Sentence
1	18346469	It is known that protein kinase C (PKC) signal transduction is enhanced in a diabetic state, and that PKC activator phorbol esters increase the gene expression of MDR1 in human tumor cells.
2	18346469	From these findings, it was suggested that STZ-induced hyperglycemia caused the upregulation of Mdr1b P-gp expression through the activation of PKCalpha and NF-kappaB.
3	21372399	Our previous study clearly revealed that intestinal P-gp expression levels were decreased via an inducible nitric oxide synthase (iNOS)-mediated mechanism in the early phases of diabetes.
4	21372399	In addition, the recovery of P-gp expression levels was completely suppressed by a non-selective NOS inhibitor.
5	21372399	Furthermore, this study shows the bidirectional effect of NOS on regulation of intestinal P-gp expression.
6	21467785	These results indicate the possibility that NO, produced by iNOS in the ileum, is involved in the alteration of ileal P-gp expression and function under STZ-induced diabetic conditions.
7	21983297	We have previously reported that ileal P-gp expression levels decrease via a nitric oxide synthase (NOS)-mediated pathway in a streptozotocin (STZ)-induced type 1 diabetic mouse model.