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Gene Information
Gene symbol: ABCG1
Gene name: ATP-binding cassette, sub-family G (WHITE), member 1
HGNC ID: 73
Synonyms: ABC8
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCA1 | 1 hits |
| 2 | ACOX1 | 1 hits |
| 3 | CYP11A1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | MAP2K3 | 1 hits |
| 6 | MAPK1 | 1 hits |
| 7 | MAPK8 | 1 hits |
| 8 | MAPK9 | 1 hits |
| 9 | NR1H3 | 1 hits |
| 10 | PPARA | 1 hits |
| 11 | STAR | 1 hits |
| 12 | UCP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19713213 | Conversely, macrophages that overexpress 12/15LO have reduced ABCG1 expression, increased transporter phosphorylation, and reduced cholesterol efflux. 12/15LO plays a key role in activating the MAPK pathway. |
| 2 | 19713213 | Inhibition of the p38 or JNK pathways with pharmacological inhibitors or dominant negative constructs blocked 12S-hydroxyeicosatetranoic acid-mediated degradation of ABCG1. |
| 3 | 19713213 | JNK2- and MKK3-, but not JNK1-deficient macrophages were resistant to the down-regulation of ABCG1 protein, reduction in efflux, and increase in serine phosphorylation by 12S-hydroxyeicosatetranoic acid. |
| 4 | 19713213 | These findings provide evidence that 12/15LO regulates ABCG1 expression and function through p38- and JNK2-dependent mechanisms, and that targeting these pathways may provide novel approaches for regulating cholesterol homeostasis. |
| 5 | 20530872 | Loss of ABCG1 expression impaired insulin secretion both in vivo and in vitro, but it had no effect on cellular cholesterol content or efflux. |
| 6 | 20811644 | The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR. |
| 7 | 20826654 | LXR ligand treatment of streptozotocin-treated rats increases expression in the sciatic nerve of steroidogenic acute regulatory protein (a molecule involved in the transfer of cholesterol into mitochondria), of the enzyme P450scc (responsible for conversion of cholesterol into pregnenolone), of 5?-reductase (an enzyme involved in the generation of neuroactive steroids) and of classical LXR targets involved in cholesterol efflux, such as ABCA1 and ABCG1. |
| 8 | 20733269 | Insulin also suppressed the expressions of mRNA and protein for ABCG1. |
| 9 | 21102330 | ApoA-I and HDL stimulate insulin secretion by interaction with ABCA1, ABCG1 or SR-BI and also inhibit apoptosis of ?-cells. |
| 10 | 18490524 | Macrophage expression of ABCG1 in both patients and control subjects was induced by treatment with the liver X receptor agonist TO-901317. |
| 11 | 20212278 | Cholesterol efflux to apoA-I and HDL3 was impaired in ABCA1(-/-) and SR-BI(-/-) adipocytes, respectively, with no effect observed in ABCG1(-/-) adipocytes. |