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Gene Information
Gene symbol: ABCG2
Gene name: ATP-binding cassette, sub-family G (WHITE), member 2
HGNC ID: 74
Synonyms: EST157481, MXR, BCRP, ABCP, CD338
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC1 | 1 hits |
| 2 | ABCC5 | 1 hits |
| 3 | CD9 | 1 hits |
| 4 | INS | 1 hits |
| 5 | INSR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19356064 | Conversely, efflux transporters Mrp2, Mrp4, and Bcrp were increased 5.4-fold, 2-fold, and 1.6-fold, respectively in type 2 diabetic kidneys with no change in levels of Mrp1, Mrp5, or Pgp. |
| 2 | 19356064 | Studies of hepatic transporters in type 2 diabetic rats reveal that the protein level of Mrp5 was reduced to 4% of control livers with no change in levels of Bcrp, Mrp1, Mrp2, Mrp4, Ntcp, or Pgp. |
| 3 | 17915193 | Insulin treatment may attenuate the impairment of Bcrp expression and function induced by diabetes. |
| 4 | 17915193 | All results gave a conclusion that STZ-induced DM may induce the impairment of function and expression of Bcrp in brain cortex, and lower levels of insulin may mainly contribute to Bcrp dysfunction in brain. |
| 5 | 21602604 | The aim of this study was to investigate the role of insulin in the regulation of breast cancer resistance protein (BCRP) function and expression using primary cultured rat brain microvessel endothelial cells (rBMECs) as an in vitro model of the blood brain barrier (BBB). |
| 6 | 21602604 | Further results showed that insulin down-regulated the function and expression of BCRP in rBMECs in a concentration-dependent manner. |
| 7 | 21602604 | Treatment with an antibody against the insulin receptor abolished the down-regulation of BCRP function and expression that was induced by insulin. |
| 8 | 21602604 | These results indicate that insulin suppressed the function and expression of BCRPs in rBMEC primary cultures. |