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Gene Information
Gene symbol: ABCG8
Gene name: ATP-binding cassette, sub-family G (WHITE), member 8
HGNC ID: 13887
Synonyms: GBD4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCG5 | 1 hits |
| 2 | FOXO1 | 1 hits |
| 3 | NPC1L1 | 1 hits |
| 4 | STN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12783625 | ABCG5 and ABCG8 (encoding sterolin-1 and sterolin-2 respectively) have been shown to be responsible for causing sitosterolemia in humans. |
| 2 | 16518588 | We examined expression of the following: (1) Niemann-Pick C1-like 1 (NPC1L1), which regulates cholesterol absorption; (2) ATP-binding cassette transporters G5 and G8 (ABCG5, ABCG8), which regulate cholesterol homeostasis through their ability to excrete enterocyte cholesterol back into the lumen of the intestine; and (3) microsomal triglyceride transfer protein (MTTP), which packages the chylomicron particle by assembling cholesterol, triglyceride, phospholipids and apolipoprotein B48. |
| 3 | 16518588 | In diabetic patients statin therapy is associated with reduced MTTP expression and increased ABCG5 and ABCG8 mRNA. |
| 4 | 18587407 | Disinhibition of the forkhead transcription factor FoxO1, increases expression of the biliary cholesterol transporters Abcg5 and Abcg8, resulting in an increase in biliary cholesterol secretion. |