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Gene Information
Gene symbol: ACACB
Gene name: acetyl-CoA carboxylase beta
HGNC ID: 85
Synonyms: HACC275, ACC2, ACCB
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACA | 1 hits |
| 2 | CPT1A | 1 hits |
| 3 | PRKAA1 | 1 hits |
| 4 | SNF1LK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15934915 | Studies in ACC2 knockout mice and in experimental animals treated with isozyme-nonselective ACC inhibitors have demonstrated the potential for treating metabolic syndrome through this modality. |
| 2 | 16721829 | In both lean and obese subjects, expression of mitochondrial ACC2 was 20-fold greater than that of cytoplasmic ACC1, consistent with their hypothesized roles in synthesizing malonyl-CoA from acetyl-CoA for CPT1 regulation and lipogenesis, respectively. |
| 3 | 16854592 | The resultant human ACC2, human ACC1, and rat ACC2 possess high specific activities, are properly biotinylated, and exhibit kinetic parameters very similar to the native ACC enzymes. |
| 4 | 18239551 | Overexpression of SIK2 repressed the expression of lipogenic genes, including FAS, acetyl CoA carboxylase 2 (ACC2), and stearoyl CoA desaturase 1 (SCD1), and reduced triglyceride content. |
| 5 | 18239551 | Reduction of endogenous SIK2 expression through RNA interference increased the expression of FAS, ACC2, and SCD1. |
| 6 | 19688337 | The AMP-activated protein kinase (AMPK) regulates lipid oxidation in muscle by inhibiting acetyl-CoA carboxylase-2 (ACC2) and increasing mitochondrial biogenesis. |