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Gene Information

Gene symbol: ACADS

Gene name: acyl-CoA dehydrogenase, C-2 to C-3 short chain

HGNC ID: 90

Synonyms: SCAD, ACAD3

Related Genes

#	Gene Symbol	Number of hits
1	ACADM	1 hits
2	INS	1 hits
3	P2RX7	1 hits

Related Sentences

#	PMID	Sentence
1	20648245	The deleted region contains amongst others: HNF1 homeobox A (HNF1A) which is important for the regulation of gene expression in the liver and involved in maturity-onset diabetes of the young type 3 and insulin resistance; acyl-CoA dehydrogenase short chain (ACADS) which encodes an enzyme important in mitochondrial fatty acid beta-oxidation and can cause short-chain acyl-CoA dehydrogenese (SCAD) deficiency, and purinergic receptor P2X7 (P2RX7) which encodes a ligand-gated ion channel, and of which polymorphisms are found with increased frequency in patients with psychiatric disorders, especially anxieties.
2	21211036	A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid ?-oxidation.
3	21211036	In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following an oral glucose load (per allele effect (?) = -3.8% (-6.3%;-1.3%), P = 0.003), reduced incremental area under the insulin curve (? = -3.6% (-6.3%;-0.9%), P = 0.009), reduced acute insulin response (? = -2.2% (-4.2%;0.2%), P = 0.03), and with increased insulin sensitivity ISIMatsuda (? = 2.9% (0.5%;5.2%), P = 0.02).