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Gene Information
Gene symbol: ACLY
Gene name: ATP citrate lyase
HGNC ID: 115
Synonyms: ATPCL, CLATP, ACL
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP3 | 1 hits |
| 2 | DDIT3 | 1 hits |
| 3 | GCK | 1 hits |
| 4 | INS | 1 hits |
| 5 | OTC | 1 hits |
| 6 | PHP | 1 hits |
| 7 | SLC37A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 6929268 | The fat diet caused significant decreases (range: 47 to 54%) in the activity of the ureogenic enzymes carbamyl phosphate synthetase, ornithine transcarbamylase and arginase; had no effect on the glycolytic enzymes glucokinase, hexokinase and pyruvate kinase; partially decreased the diabetes-induced elevated activities of the gluconeogenic enzymes phosphoenolpyruvate carboxykinase (63% decrease), serine dehydratase (90%), alanine aminotransferase (31%) and aspartate aminotransferase (65%), and partially reversed the activity of one lipogenic enzyme, ATP citrate lyase. |
| 2 | 6135416 | The increase in hepatic lipogenesis in T3-treated 48 h-starved rats after intragastric glucose feeding was prevented by short-term insulin deficiency, but not by (-)-hydroxycitrate, an inhibitor of ATP citrate lyase. |
| 3 | 16497337 | The activity of glucose-6-phosphatase was significantly increased while the activities of ATP citrate lyase, pyruvate kinase and glucose-6-phosphate dehydrogenase were significantly reduced in the kidney of the diabetic control rats compared to the normal group. |
| 4 | 20693577 | ACLY inhibitors alone were sufficient to induce CCAAT/enhancer-binding protein homologues protein (CHOP)-dependent ER stress and caspase-3-dependent apoptosis. |
| 5 | 20501872 | Silencing of PHP expression markedly reduced ACL activity, suggesting functional regulation of ACL by PHP in beta-cells. |