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Gene Information
Gene symbol: ADAM17
Gene name: ADAM metallopeptidase domain 17
HGNC ID: 195
Synonyms: cSVP, CD156B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | SIRT1 | 1 hits |
| 3 | TIMP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19581416 | Here, we show that in human carotid atherosclerotic plaques, TIMP3 was significantly reduced in subjects with type 2 diabetes, leading to ADAM17 and MMP9 overactivity. |
| 2 | 19581416 | In atherosclerotic plaques from subjects with type 2 diabetes, the deregulation of ADAM17 and MMP9 activities is related to inadequate expression of TIMP3 via SirT1. |
| 3 | 19633828 | The regulation of TNF-alpha converting enzyme (TACE) and its inhibitor, tissue inhibitor of metalloproteinase 3 (TIMP3), in human type 2 diabetes is unknown. |
| 4 | 19633828 | TACE expression, and TACE, TNF-alpha, TNFR1 and IL-6R levels were increased in type 2 diabetes, and positively correlated with insulin resistance. |
| 5 | 19633828 | A 6 h lipid infusion into NGT individuals decreased insulin-stimulated glucose metabolism by 25% with increased TACE, decreased expression of the gene encoding TIMP3 and increased IL-6R release. |
| 6 | 19633828 | TACE activity was increased in skeletal muscle of obese type 2 diabetes patients and in lipid-induced insulin resistance. |
| 7 | 21984580 | TIMP3 was also reduced, along with insulin resistance, resulting in increased ectodomain shedding activity of the metalloprotease ADAM17. |