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Gene Information
Gene symbol: ADCYAP1
Gene name: adenylate cyclase activating polypeptide 1 (pituitary)
HGNC ID: 241
Synonyms: PACAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADCY10 | 1 hits |
| 2 | CGA | 1 hits |
| 3 | FSHB | 1 hits |
| 4 | FST | 1 hits |
| 5 | GNRHR | 1 hits |
| 6 | INS | 1 hits |
| 7 | NOS2A | 1 hits |
| 8 | VIPR1 | 1 hits |
| 9 | VIPR2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8663363 | For each splice variant, PACAP (both PACAP-38 and PACAP-27) had similar affinity and potency for stimulating either adenylate cyclase or phospholipase C. |
| 2 | 12686458 | Insulin and cyclic adenosine monophosphate (cAMP) generation induced by PACAP were investigated in islets isolated from the spontaneously diabetic Goto-Kakizaki (GK) rat. |
| 3 | 12686458 | PACAP significantly potentiated glucose-stimulated insulin release in isolated islets of normal but not of GK rats. |
| 4 | 12686458 | In conclusion, using improved immunocytochemistry techniques and electron microscopy (EM), PACAP was shown to be expressed both in normal and diabetic islet cells and localized to secretory granules of insulin and glucagon cells. |
| 5 | 16730098 | Pituitary adenylate cyclase-activating peptide (PACAP) is a ubiquitous peptide of the glucagon superfamily that is involved in glucose homeostasis and regulation of insulin secretion. |
| 6 | 16730098 | Feeding activity, body weight, basal plasma glucose and plasma insulin concentrations were not significantly affected by chronic PACAP(6-27) treatment. |
| 7 | 16730098 | However, PACAP(6-27) treatment impaired glucose tolerance, insulin sensitivity and the glycaemic response to feeding. |
| 8 | 17559974 | Both peptides bind to their common G-protein-coupled receptors, VPAC1 and VPAC2, and PACAP, in addition to the specific receptor PAC1, all three of which are expressed in islets. |
| 9 | 21191111 | PACAP increases alpha-subunit (Cga) and Lhb mRNAs, and it stimulates the transcription of follistatin (Fst) that, in turn, restrains activin signaling to repress Fshb and gonadotropin-releasing hormone-receptor (Gnrhr) expression as well as other activin-responsive genes. |
| 10 | 21191111 | At birth, pituitary PACAP declines and pituitary follistatin levels decrease, which together with increased gonadotropin-releasing hormone secretion allow Gnrhr and Fshb to increase and facilitate activation of the newborn gonads. |
| 11 | 11071874 | In the present study, we investigated the cytoprotective effect of PACAP in the cytokine-exposed mice beta-cell line, beta TC cells. 1 x 10(-8) M PACAP inhibited the reduction of cell viability, NO production, expression of iNOS mRNA, and iNOS promoter activity caused by the combination of three proinflammatory cytokines. |