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Gene Information
Gene symbol: ADFP
Gene name: adipose differentiation-related protein
HGNC ID: 248
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | FASN | 1 hits |
| 3 | INS | 1 hits |
| 4 | INSR | 1 hits |
| 5 | IRS2 | 1 hits |
| 6 | KIAA1881 | 1 hits |
| 7 | LEP | 1 hits |
| 8 | M6PRBP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17484887 | ADRP ASO specifically decreased ADRP mRNA and protein levels in the livers of Lep(ob/ob) and DIO mice, without altering the levels of other lipid droplet proteins, that is, S3-12 and TIP47. |
| 2 | 17484887 | The reduction in hepatic steatosis by ADRP ASO was associated with improvement in glucose homeostasis in both Lep(ob/ob) and DIO mice. |
| 3 | 17484887 | Reduction in hepatic ADRP level using an antisense oligonucleotide reverses hepatic steatosis, hypertriglyceridemia, and insulin resistance in obese mice, suggesting that ADRP may be targeted for the treatment of NAFLD and associated lipid and glucose abnormalities. |
| 4 | 18669627 | The lipid droplet protein adipose differentiation-related protein (ADRP) mediates hepatic steatosis, but whether this affects insulin action in the liver or peripheral organs in diet-induced obesity is uncertain. |
| 5 | 18669627 | ADRP ASO increased the phosphorylation of insulin receptor substrate (IRS)1, IRS2, and Akt, and decreased gluconeogenic enzymes and PKCepsilon, consistent with its insulin-sensitizing action. |
| 6 | 19086646 | Puerarin can decrease the blood glucose level of T2DM by downregulating ADRP mRNA expression and depressing the insulin resistance. |
| 7 | 19602560 | This study aimed to explore the role of the PAT proteins OXPAT and ADRP in skeletal muscle lipid metabolism and their putative role in modulating insulin sensitivity. |
| 8 | 20484013 | The downregulation of ADFP in MIN6 cells by antisense oligonucleotide (ASO) suppressed the accumulation of triglycerides upon fatty acid loading (56% of control) along with a reduction in the mRNA levels of lipogenic genes such as diacylglycerol O-acyltransferase-2 and fatty acid synthase. |
| 9 | 20484013 | Moreover, the reduction of ADFP impaired the ability of palmitate to increase insulin secretion. |
| 10 | 20484013 | These findings demonstrate that ADFP is important in regulation of lipid metabolism and insulin secretion in beta-cells. |
| 11 | 15111493 | We furthermore demonstrate that the expression of S3-12 and perilipin is reduced in obese compared with lean Zucker rats, whereas the expression of adipophilin is increased. |