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Gene Information
Gene symbol: ADRB3
Gene name: adrenoceptor beta 3
HGNC ID: 288
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FFAR1 | 1 hits |
| 2 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11288039 | The beta(3)-adrenergic receptor (AR) gene variant (Trp64Arg) has been reported to be associated with obesity and insulin resistance in humans. |
| 2 | 18249022 | The functional variant Trp64Arg in the beta(3)-adrenergic receptor has previously been examined for association with obesity and insulin resistance with ambiguous results. |
| 3 | 20416356 | The free fatty acid (FFA) receptor GPR40, expressed by pancreatic beta-cells, may be responsible for insulin release following beta(3) adrenoceptor (Adrb3) activation. |
| 4 | 20416356 | To test this hypothesis, we first studied the effects of Adrb3 agonists SR58611A and CL316,243 in GPR40 knockout (GPR40(-/-)) mice. |
| 5 | 20416356 | Our data indicate that insulin secretion, a secondary event following stimulation of Adrb3 receptors, is partially mediated by GPR40 and suggest that GPR40 is integral to the anti-diabetes effects of Adrb3 agonists. |