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Gene Information

Gene symbol: AIFM1

Gene name: apoptosis-inducing factor, mitochondrion-associated, 1

HGNC ID: 8768

Synonyms: AIF

Related Genes

# Gene Symbol Number of hits
1 CASP3 1 hits
2 FOXM1 1 hits
3 PARP1 1 hits
4 SOCS1 1 hits

Related Sentences

# PMID Sentence
1 15054118 The role of PARP in regulating AIF translocation in myocytes also was confirmed in an isolated perfused heart preparation.
2 15054118 Overall, the current results demonstrate the importance of the PARP pathway in diabetic rats subjected to myocardial infarction and demonstrate the role of PARP in regulating AIF translocation in MI/R.
3 16728389 Expression of iPLA2 in INS-1 cells prevented the loss of mitochondrial membrane potential, attenuated the release of cytochrome c, Smac/DIABLO, and apoptosis inducing factor from mitochondria, and reduced mitochondrial reactive oxygen species production.
4 19094082 Thus, nuclear translocation of AIF could underlie the increased death, whereas fragmentation of caspase 3 could be associated with the morphological changes found in hypothalamic astrocytes of diabetic rats.
5 20832564 The Ad5F35-SOCS1-infected islets with higher SOCS1 expression showed decreased levels of active caspase 3 and intranuclear AIF after treatment with tumor necrosis factor-? and cycloheximide in vitro.
6 20832564 These results demonstrated that the expression of SOCS1 in islet grafts protected them from apoptosis through caspase 3 dependent and AIF caspase-independent-pathways.