- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: AIRE
Gene name: autoimmune regulator
HGNC ID: 360
Synonyms: PGA1, APS1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | HPT | 1 hits |
| 3 | INS | 1 hits |
| 4 | MOG | 1 hits |
| 5 | TRA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12564102 | APS-I or APECED syndrome appears in children firstly affected by recurrent muco-cutaneous candidiasis and hypoparathyroidism, followed by adrenocortical insufficiency and by other autoimmune processes. |
| 2 | 16246524 | However, differences in insulin mRNA expression among different thymi were far wider than those determined by the class I and class III insulin gene alleles and maintained a clear correlation with AIRE expression. |
| 3 | 18414681 | Homozygous loss-of-function mutations in AIRE cause autoimmune polyglandular syndrome type 1 (APS 1), which manifests in a classic triad of hypoparathyroidism, adrenal insufficiency, and candidiasis. |
| 4 | 21108470 | The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. |
| 5 | 21108470 | Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE). |
| 6 | 20876716 | We generated six class I and two class III VNTR constructs linked to the human insulin basal promoter or SV40 heterologous promoter/enhancer and demonstrated that AIRE protein modulates the insulin promoter activities differentially through binding to the VNTR region. |
| 7 | 20876716 | Here we show that in the presence of the autoimmune regulator (AIRE), the class III VNTR haplotype is responsible for an average of three-fold higher insulin expression than class I VNTR in thymic epithelial cells. |
| 8 | 20876716 | Further, the transcriptional activation of the INS-VNTR by AIRE requires the insulin basal promoter. |
| 9 | 20876716 | These findings demonstrate a type 1 diabetes predisposition encoded by the INS-VNTR locus and a critical function played by AIRE, which constitute a dual control mechanisms regulating quantitative expression of insulin in human thymic epithelial cells. |
| 10 | 18768863 | Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1. |