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Gene Information
Gene symbol: ALPL
Gene name: alkaline phosphatase, liver/bone/kidney
HGNC ID: 438
Synonyms: TNSALP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALPI | 1 hits |
| 2 | COL1A1 | 1 hits |
| 3 | RUNX2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20674184 | TNF-? and IL-1? have indeed been shown to stimulate in vitro the expression by vascular smooth muscle cells (VSMCs) of tissue-non specific alkaline phosphatase (TNAP), a key enzyme in the mineralization process, and to trigger the trans-differentiation of VSMCs into osteoblast-like cells, expressing the master transcription factor RUNX2. |
| 2 | 20674184 | We propose that this stimulation of TNAP in VSMCs in vitro and in vivo may be sufficient to induce the calcification of collagen fibrils, and that the absence of crystal clearance, in turn, induces the differentiation of VSMCs and/or mesenchymal stem cells into bone-forming cells, eventually leading to formation of a bone-like tissue. |
| 3 | 21555997 | Tumor necrosis factor (TNF)-? and interleukin (IL)-1? stimulate tissue non-specific alkaline phosphatase (TNAP) activity and mineralization in cultures of vascular smooth muscle cells (VSMCs). |