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Gene Information
Gene symbol: ANGPT1
Gene name: angiopoietin 1
HGNC ID: 484
Synonyms: KIAA0003, Ang1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | ANGPT2 | 1 hits |
| 3 | ANPEP | 1 hits |
| 4 | HIF1A | 1 hits |
| 5 | INS | 1 hits |
| 6 | NOS3 | 1 hits |
| 7 | PDGFA | 1 hits |
| 8 | TEK | 1 hits |
| 9 | TNF | 1 hits |
| 10 | TPPP3 | 1 hits |
| 11 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21963653 | Niaspan treatment attenuated Ang2, but increased Ang1 expression in the ischemic brain in T1DM-MCAo-rats. |
| 2 | 15774928 | Angiopoietin 1 and 2 interact with vascular endothelial growth factor (VEGF) to promote angiogenesis in animal and in vitro models. |
| 3 | 15774928 | Angiopoietin 2 is the natural antagonist of angiopoietin 1 which is thought to act as an anti-permeability agent. |
| 4 | 17065527 | Retinal mRNA expression of VEGF, angiopoietin-1 and -2, and PDGF was examined at days P14 and P20. |
| 5 | 18318806 | Mice were killed 3, 6, and 12 days after skin injury to measure vascular endothelial growth factor (VEGF) mRNA expression and protein synthesis, to assay angiogenesis and tissue remodeling through histological evaluation, and to study CD31, Angiopoietin-1 and Transglutaminase-II. |
| 6 | 18436850 | In pericytes undergoing apoptosis induced by either TNF-alpha or high glucose Ang-1 increased survival (P < 0.05 for TNF-alpha; P < 0.01 for high glucose), whereas Ang-2 increased apoptosis. |
| 7 | 18436850 | Ang-1 enhanced CD13 expression in a dose-dependent manner (P < 0.05) and stimulated pericyte migration in a synthetic matrix wound-healing assay that was associated with a change in F-actin organization. |
| 8 | 18078386 | In conclusion, our results provide strong evidence that Ang-1 gene transfer improves the delayed wound repair in diabetes by inducing angiogenesis in a VEGF-independent manner. |
| 9 | 18835934 | We investigated the potential roles and intracellular mechanisms of angiopoietin-1 (Ang-1) gene therapy on myocardial HIF-1alpha stabilization and vascular maturation in db/db mice. db/db mice were systemically administrated adenovirus Ang-1 (Ad-CMV-Ang-1). |
| 10 | 18835934 | Ang-1 gene therapy causes a significant increase in Akt and eNOS expression and HIF-1alpha stabilization. |
| 11 | 18835934 | Taken together, our data show that Ang-1 increases myocardial vascular maturation and angiogenesis together with suppression of PHD2 and the upregulation of HIF-1alpha signaling. |
| 12 | 21113176 | Ang-1 (250 ng/mL) increased Tie-2 activation, inhibited cell apoptosis, and promoted angiogenesis. |
| 13 | 21113176 | Ang-1 activates the Tie-2 pathway and restores hyperglycemia-induced myocardial microvascular endothelial dysfunction. |
| 14 | 18408125 | Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are the two ligands of the Tie-2 receptor, a receptor tyrosine kinase that is expressed on the endothelium. |
| 15 | 11310829 | For both normal and impaired healing conditions, we observed a constitutive expression of Ang-1, which was paralleled by an increase of Ang-2 upon injury. |
| 16 | 17596403 | Cultured islets expressing Ang-1 displayed improved viability and enhanced glucose-stimulated insulin secretion in the presence of cytokines. |
| 17 | 19958114 | RT-PCR revealed that the expression of VEGF, VEGF receptors, STAT3, erythropoietin, erythropoietin receptor, STAT5, angiopoietin 2, and Tie2 mRNA increased in the DM group, whereas angiopoietin 1 expression decreased. |
| 18 | 21660636 | Circulating concentrations of angiogenin, angiopoietin-1, platelet derived endothelial factor (PDGF)-AA, matrix metalloproteinase (MMP) 8 and 9, endothelial growth factor (EGF) and vascular EGF (VEGF) were also measured. |