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Gene Information
Gene symbol: AOC3
Gene name: amine oxidase, copper containing 3 (vascular adhesion protein 1)
HGNC ID: 550
Synonyms: VAP1, HPAO, VAP-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | INS | 1 hits |
| 3 | INSR | 1 hits |
| 4 | IRS1 | 1 hits |
| 5 | KRT124P | 1 hits |
| 6 | MAOB | 1 hits |
| 7 | SLC2A4 | 1 hits |
| 8 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2218072 | Semicarbazide-sensitive amine oxidase (SSAO) activity was investigated in serum and tissues of streptozotocin diabetic rats. |
| 2 | 12686100 | The combination of SSAO substrates and low concentrations of vanadate markedly stimulates glucose transport and GLUT4 glucose transporter recruitment to the cell surface in rat adipocytes by a mechanism that requires SSAO activity and hydrogen peroxide formation. |
| 3 | 12686100 | Substrates of SSAO such as benzylamine or tyramine in combination with vanadate potently stimulate tyrosine phosphorylation of both insulin-receptor substrates 1 (IRS-1) and 3 (IRS-3) and phosphatidylinositol 3-kinase (PI 3-kinase) activity in adipose cells, which occurs in the presence of a weak stimulation of insulin-receptor kinase. |
| 4 | 12686114 | It has been speculated that production of cytotoxic products of SSAO may cause endothelial damage and thus contribute to the development of diabetic vascular complications such as retino-, nephro-, and neuropathies as a result of SSAO activity.In order to explore the possibility that high SSAO activity contributes to the development of vascular complications in diabetes, we have performed two studies in patients with Type-2 diabetes quantifying plasma SSAO activity, HbA(1c), and urinary levels of the SSAO substrate, methylamine. |
| 5 | 14978192 | Finally, benzylamine was unable to stimulate insulin secretion by isolated pancreatic islets from both species and SSAO activity was hardly detectable in pancreas. |
| 6 | 15178639 | To investigate the origin of circulating SSAO activity, two transgenic mouse models were created with full-length human VAP-1 (hVAP-1) expressed on either endothelial (mTIEhVAP-1) or adipose tissues (aP2hVAP-1), with tie-1 and adipocyte P2 promoters, respectively. |
| 7 | 16180338 | While TNFalpha produced a decrease on VAP-1/SSAO membrane form content, isoproterenol did not modify it. |
| 8 | 19635478 | Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule that possesses semicarbazide-sensitive amine oxidase (SSAO) activity and is involved in leukocyte recruitment. |