Ignet

Gene Information

Gene symbol: APLN

Gene name: apelin

HGNC ID: 16665

Synonyms: apelin, XNPEP2

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	AGT	1 hits
3	AGTRL1	1 hits
4	AKT1	1 hits
5	COL1A1	1 hits
6	COL2A1	1 hits
7	EPHB2	1 hits
8	IL1B	1 hits
9	INS	1 hits
10	NOS3	1 hits
11	TNF	1 hits
12	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	17359956	Apelin treatment strikingly reversed the altered aortic vascular responsiveness to Ang II and acetylcholine in db/db mice, both of which were abolished by the eNOS inhibitor NG-nitro-L-arginine methyl ester.
2	17359956	Finally, in db/db mice, considerable increases in phosphorylation of Akt on serine 473 and of eNOS on serine 1177 were found in aortas pretreated with apelin.
3	17359956	Apelin treatment modulates the abnormal aortic vascular tone in response to Ang II and acetylcholine by potentiating phosphorylation of Akt and eNOS in diabetic mice, suggesting that the apelin-APJ system might be an important regulator of vascular function in diabetes.
4	18484561	To investigate blood apelin concentrations in patients with newly diagnosed and untreated type 2 diabetes mellitus (T2DM) who had no additional disorder and to investigate the association of apelin with adiponectin, body mass indexes (BMI) and insulin sensitivity.
5	19344973	Apelin is an endogenous ligand for human orphan G-protein-coupled receptor, APJ and increases NO generation.
6	19940327	Adipose tissue produces multiple cytokines(TNF-alpha, IL-6, PAI-1, CRP, angiotensinogen, leptin, adiponectin, visfatin, apelin, resistin)which decrease insulin sensitivity and induce inflammatory processes, endothelial dysfunction,and atherosclerosis.
7	19861585	The recently discovered peptide apelin is known to be involved in the maintenance of insulin sensitivity.
8	19861585	Fasting glucose, insulin, and adiponectin levels were determined on mice with generalized deficiency of apelin (APKO).
9	20890241	Intravitreal bevacizumab injection may lead to a decrease in the intraocular and systemic concentrations of VEGF, suggesting a local and potentially a systemic effect on VEGF but may have no effect on apelin.
10	20890241	Apelin may be associated with the development of epiretinal membranes in proliferative diabetic retinopathy and may not directly correlate with VEGF.
11	21264801	Furthermore we examined the association of apelin serum levels with insulin sensitivity/resistance and body fat distribution as probably dependent cardiovascular risk factors.
12	21264801	Furthermore, neither parameters of insulin sensitivity like insulin sensitivity index (ISI), nor fat distribution like BMI, grade of adiposity, total adipose tissue or VAT were associated with apelin serum levels.
13	18457011	In this regard, expression of apelin gene in adipose tissue is increased by insulin and TNFalpha.
14	20233941	Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue (AT) and plasma with obesity.
15	20233941	However, the regulation of apelin and APJ (apelin receptor) expression in skeletal muscle in relation to insulin resistance or type 2 diabetes is not known.
16	20664951	In vitro, we examined the effects of apelin on normal chondrocyte proliferation and gene expression of metalloproteinases (MMPs) and interleukin-1beta (IL-1beta).
17	20664951	Apelin stimulated the proliferation of chondrocytes and significantly increased mRNA levels of MMP-1, -3, -9 and IL-1beta in vitro.
18	20664951	Intra-articular injection with apelin in vivo up-regulated the expression of MMP-3, -9, and IL-1beta as well as decreased the level of collagen II.
19	21395477	Apelin and its receptor have emerged as promising targets for the treatment of insulin resistance.
20	21395477	Indeed, peripheral administration of apelin stimulates glucose utilization and insulin sensitivity via a nitric oxide (NO) pathway.
21	21762740	We also demonstrated that apelin treatment normalizes the diabetes induced alteration of AKT and ERK activations in the pancreas of Akita mice.